【摘要】 中医药在延缓艾滋病感染者发病、调节免疫功能、改善临床症状、提高生存质量等方面具有优势，但由于艾滋病临床症状复杂多样，中医证候多虚实夹杂，临床辨治组方配伍药味较多，造成单一靶点和途径难以阐明中医药治疗HIV/AIDS的作用机制。本文通过查阅国内外文献，对HIV/AIDS肠道微生态研究现状及肠道微生态在中医药防治艾滋病临床实践进行综述，提出应用16s rDNA、宏基因组、流式细胞术、ELISA等技术，对艾滋病患者的肠道菌群多样性、肠黏膜屏障通透性和完整性改变、肠道免疫进行研究，进一步研究中医药通过调控肠道菌群对肠道粘膜屏障及肠道免疫的保护作用，明确中医药对肠道微生态调控发挥的多靶点、多环节作用的内在机制。更多还原

【Abstract】 Traditional Chinese medicine(TCM) has advantages in delaying the onset of disease in HIV-infected individuals, regulating immune function, improving clinical symptoms, and enhancing the quality of life. However, due to the complex and diverse clinical symptoms of HIV/AIDS,TCM syndrome is characterized by Xushijiaza(虚实夹杂),leading to the use of multiple Chinese herbal drugs in clinical treatment. This complexity makes it challenging to elucidate the mechanisms of action of TCM in the treatment of HIV/AIDS,as it does not act on a single target or pathway. This study reviewed the current status of research on the intestinal microecology in HIV/AIDS and its clinical application in TCM practice, proposed the use of techniques such as 16s rDNA sequencing, metagenomics, flow cytometry, and ELISA to study the diversity of gut microbiota in HIV/AIDS patients, changes in intestinal mucosal barrier permeability and integrity, and intestinal immune responses, and further investigated how TCM regulated the gut microbiota to protect the intestinal mucosal barrier and enhance intestinal immunity. This study is expected to clarify the underlying mechanisms by which TCM exerts its multi-target and multi-stage effects on the regulation of intestinal microecology.更多还原