【摘要】 由于呼吸道病毒具有相似的组织嗜性、传播途径、易感人群，当多种呼吸道病毒叠加流行时，常发生混合感染。特定呼吸道病毒之间的混合感染会引发更为严重的疾病后果，增加临床治疗的难度。目前，病毒混合感染的致病机制仍不明确，也缺少针对呼吸道病毒混合感染的有效防治策略。在宿主细胞内，不同病毒间的相互作用存在正向促进或负向抑制的差异，相同的信号通路和宿主因子也可能参与了多个病毒的感染周期。本文综述了呼吸道病毒混合感染的临床研究进展及其危害，总结了呼吸道病毒混合感染的相互作用关系和致病机制，提出了广谱疫苗和抗病毒药物在防治病毒混合感染方面的应用前景，为呼吸道病毒混合感染的防治提供了可参考的科学见解。更多还原

【Abstract】 Respiratory viruses, characterized by similar tissue tropisms, transmission routes, and susceptible populations, often lead to co-infections during concurrent outbreaks. Co-infections between specific respiratory viruses can result in more severe disease outcomes, increasing the complexity of clinical management. Currently, the pathogenic mechanisms under respiratory virus co-infections are not fully understood, and there is a lack of effective prevention and treatment strategies for respiratory virus co-infections. Within host cells, interactions between different viruses can either be positive to accelerate replication of both viruses or be negative to hinder viral replication. Besides, the same signaling pathways and host factors may be involved in the infection cycles of multiple viruses. This article reviews the clinical research progress and the significance of respiratory virus co-infections, summarizes and discusses the molecular interactions between respiratory viruses, and proposes potential applications for broad-spectrum vaccines and broad-spectrum antivirals in the prevention and treatment of co-infections, providing valuable scientific insights for respiratory virus co-infections.更多还原