【摘要】 目的 分析新疆生物安全实验室（biosafety laboratory,BSL）人员焦虑现况及其影响因素。方法 于2021年，采用整群抽样的方式，选取新疆106个县的各相关疾控中心单位实验室、医院检验科等部门的8 500名BSL工作人员为研究对象，采用《焦虑自评量表》（Self-Rating Anxiety Scale,SAS）进行问卷调查；采用logistic回归模型分析焦虑的可能影响因素。结果 回收有效问卷7 924份，有效回收率为93.2%。焦虑检出率为34.93%(2 768/7 924)。其中轻度焦虑检出率为19.95%，中度焦虑检出率为8.99%，重度焦虑检出率为5.99%。logistic回归分析结果显示：女性相对于男性发生焦虑的风险更大（OR=1.418,P <0.05）；相比<24岁者，30～44、≥50岁者更容易发生焦虑（OR=1.298、1.482,P <0.05）；相比未婚，已婚者发生焦虑的风险上升（OR=1.159,P <0.05）；相比无请假者，有请假者发生焦虑的风险升高（OR=1.228～4.405,P <0.05）；相比工龄≤5年者，工龄6年及以上发生焦虑危险性升高（OR=1.444、2.002,P <0.05）；相比实验技术人员，后勤、工程人员发生焦虑危险性上升（OR=1.280,P <0.05）；相比固定白班者，倒班者发生焦虑的危险性上升（OR=2.051,P <0.05）；患冠心病、消化性溃疡者发生焦虑危险性上升（OR=1.848、2.951,P <0.05）；相比中专及以下学历者，本科及以上学历者发生焦虑的危险性降低（OR=0.685,P <0.05）；相比不运动者，每周运动者发生焦虑的危险性降低（OR=0.708～0.775,P <0.05）；相比睡眠质量差者，睡眠质量良好者发生焦虑的危险性降低（OR=0.201,P <0.05）；相比月均收入3 000元以下者，月收入≥4 000元者发生焦虑的危险性降低（OR=0.685～0.771,P <0.05）。结论 新疆BSL工作人员焦虑发生率较高，影响因素是多方面的，应重视对其的评估与干预。相关部门应从多个层面加以干预，减少员工焦虑情绪的发生。更多还原

【Abstract】 Objective To analyze the anxiety status and influencing factors among biosafety laboratory(BSL) personnel in Xinjiang. Methods In 2021, a total of 8 500 BSL workers from disease control centers, hospital laboratories, and other related departments in 106 counties of Xinjiang, selected by a cluster sampling method, were surveyed with the Self-Rating Anxiety Scale(SAS). The logistic regression model was used to analyze the possible influencing factors for anxiety. Results A total of 7 924 valid questionnaires were collected, with an effective recovery rate of 93.2%. The anxiety detection rate was 34.93%(2 768/7 924), including 19.95% mild anxiety, 8.99% moderate anxiety, and 5.99% severe anxiety. The logistic regression analysis showed that the females had a higher risk of developing anxiety than the males(OR = 1.418, P< 0.05). Compared with those aged < 24, those aged 30-44 and over 50 were more likely to develop anxiety(OR =1.298, 1.482, P < 0.05). Compared with the unmarried, the married had an increased risk of developing anxiety(OR =1.159, P < 0.05). Compared with those without asking for leave, those asking for leave had an increased risk of developing anxiety(OR = 1.228-4.405, P < 0.05). Compared with those with working time ≤ 5 years, those with working time over 6 years had an increased risk of developing anxiety(OR = 1.444, 2.002, P < 0.05). Compared with experimental technicians, logistics and engineering personnel had an increased risk of developing anxiety(OR = 1.280, P <0.05). Compared with workers with a fixed-day shift, shift workers had an increased risk of developing anxiety(OR =2.051, P < 0.05). The workers with coronary heart disease and peptic ulcer had an increased risk of developing anxiety(OR = 1.848, 2.951, P < 0.05) compared with workers without this disease. Compared with those with technical secondary school and below, those with the bachelor degree or above had a reduced risk of developing anxiety(OR = 0.685, P <0.05). Compared with those who did not exercise, those who exercised weekly had a reduced risk of developing anxiety(OR = 0.708-0.775, P < 0.05). Compared with those with poor sleep quality, those with good sleep quality had a reduced risk of developing anxiety(OR = 0.201, P < 0.05). Compared with those with an average monthly income of less than 3 000 yuan, those with a monthly income of more than 4 000 yuan had a reduced risk of developing anxiety(OR =0.685-0.771, P < 0.05). Conclusions The anxiety incidence rate of BSL workers in Xinjiang was high, and the influencing factors were multifaceted. The evaluation and intervention of their anxiety should be paid attention to. Relevant departments should intervene at multiple levels to improve the occurrence of employees ’anxiety.更多还原