【摘要】 目的 制备槲皮素纳米晶提高其溶出速率，并考察不同稳定剂种类和比例对纳米晶稳定性的影响。方法 采用溶剂超声法制备槲皮素纳米晶，分别比较3种不同稳定剂（聚维酮K30、泊洛沙姆F188、十二烷基硫酸钠），以粒径为筛选指标考察放置的稳定性，并结合扫描电镜、红外光谱和X射线衍射的方法，表征纳米晶的微观形态，以及探讨稳定剂与纳米晶的作用机制。结果 通过试验筛选，结果显示聚维酮K30的稳定性能最好，纳米晶同样为棒状结晶形态，纳米晶的溶出速率较原料药有了明显的提高。结论 稳定剂的种类和用量会影响纳米晶的稳定性。更多还原

【Abstract】 Objective To prepare quercetin nanocrystals, improve their dissolution rate, and investigate the effects of different stabilizer types and ratios on the stability of nanocrystals. Methods Quercetin nanocrystals were prepared by solvent ultrasonication, and three different stabilizers(polyvinylpyrrolidone-K30, poloxamer F188 and sodium dodecyl sulfate) were compared. The particle size was used as a screening index to investigate the stability of placement, the microscopic morphology of nanocrystals was characterized by scanning electron microscopy, infrared spectroscopy and X-ray diffraction, and the mechanism of action between stabilizers and nanocrystals was discussed. Results Through experimental screening, the results showed that povidone K30 had the best stable performance, the nanocrystals were also in the form of rod crystals, and the dissolution rate of nanocrystals was significantly higher than that of active pharmaceutical ingredients. Conclusion The type and amount of stabilizer will affect the stability of nanocrystals.更多还原