【摘要】 目的：研究全腹腔镜下胃部分切除联合胃肠吻合手术在胃癌合并幽门梗阻患者中的治疗效果。方法：选择我院于2023年1月—2024年1月期间收治的120例胃癌合并幽门梗阻患者为研究对象，采用随机分配的方式分为对照组（60例，采取开腹手术治疗方法）和观察组（60例，采取全腹腔镜胃部分离断后胃肠吻合术治疗），比较两组炎性因子水平、围术期相关指标（手术时间、出血量、住院时间、首次下床及进食时间、胃管留置时长）、生存质量评分以及并发症发生率。结果：观察组C反应蛋白、肿瘤坏死因子和白细胞介素-6水平低于对照组（P<0.05）；两组手术时间比较，差异无统计学意义（P>0.05），而观察组出血量少于对照组，住院时间、首次下床活动时间、首次进食时间、胃管留置时长短于对照组（P<0.05）；观察组生存质量各维度评分低于对照组（P<0.05）。结论：全腹腔镜胃部分切除后胃肠吻合术可减轻胃癌合并幽门梗阻患者机体炎性反应、促进术后恢复、提高生存质量，并降低并发症发生率。更多还原

【Abstract】 Objective: To study the therapeutic effect of total laparoscopic partial gastrectomy combined with gastrointestinal anastomosis in patients with gastric cancer complicated with pyloric obstruction. Methods: A total of 120 patients with gastric cancer complicated with pyloric obstruction admitted to our hospital from January 2023 to January 2024 were selected as the research objects. They were randomly divided into control group(60 patients, treated with open surgery) and observation group(60 patients, treated with total laparoscopic gastrointestinal anastomosis after gastric separation). The levels of inflammatory factors, perioperative related indicators(operation time, bleeding volume, hospitalization time, first time to get out of bed and eating time, gastric tube indwelling time), quality of life score and complication rate were compared between the two groups. Results: The levels of C-reactive protein, tumor necrosis factor and interleukin-6 in the observation group were lower than those in the control group(P<0.05). There was no statistically significant difference in the surgical time between the two groups(P>0.05), while the observation group had less bleeding than the control group, and shorter hospitalization time, first time getting out of bed, first time eating, and gastric tube retention time than the control group(P<0.05). The scores of various dimensions of quality of life in the observation group were lower than those in the control group(P<0.05). Conclusion: Gastrointestinal anastomosis after total laparoscopic partial gastrectomy can reduce the inflammatory response of patients with gastric cancer complicated with pyloric obstruction, promote postoperative recovery, improve the quality of life, and reduce the incidence of complications.更多还原