【摘要】 目的 观察融合加味凉膈散的中西医结合疗法治疗脓毒症（热毒炽盛证）的临床疗效。方法 将患者随机分为治疗组（西医常规治疗+加味凉膈散颗粒剂）和对照组（西医常规治疗），两组疗程均14 d，观察临床疗效，比较两组第28天生存率以及治疗前后序贯性器官功能衰竭量表（SOFA）评分、急性生理与慢性健康量表（APACHEⅡ）评分、中医证候评分、血常规、C反应蛋白（CRP）、血乳酸、降钙素原（PCT）、肿瘤坏死因子（TNF-α）、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肝素结合蛋白（HBP）的差异。结果 治疗组、对照组的第28天生存率分别为77.46%、63.89%，治疗组明显优于对照组（P <0.05）。治疗后，治疗组SOFA评分、APACHEⅡ评分和中医证候评分均低于对照组（P <0.05），白细胞计数（WBC）、中性粒细胞百分比、TNF-α、IL-6、HBP、PCT明显低于对照组（P <0.05）。结论 融合加味凉膈散的中西医结合治疗脓毒症（热毒炽盛证）具有良好的疗效。更多还原

【Abstract】 Objective:To observe the clinical efficacy of integrated traditional Chinese and western medicine using Modified Liangge Powder for treating sepsis(syndrome of blazing heat-toxin). Methods:Patients were randomly divided into a treatment group(conventional western medicine treatment plus modified Liangge powder granules)and a control group(conventional western medicine treatment). Both groups received a 14 day course of treatment. The clinical efficacy was observed,and the cumulative survival rate on day 28,Sequential Organ Failure Assessment(SOFA)scores,Acute Physiology and Chronic Health EvaluationⅡ（APACHEⅡ）scores,TCM syndrome scores,complete blood count,C-reactive protein,blood lactate,procalcitonin(PCT),tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),and heparin-binding protein(HBP)were compared before and after treatment between the two groups. Results:The cumulative survival rates on day 28 for the treatment and control groups were 77.46% and 63.89%,respectively,with the treatment group showing significantly better survival(P < 0.05). After treatment,the SOFA scores,APACHEⅡ scores,and TCM syndrome scores were significantly lower in the treatment group than in the control group(P < 0.05). The treatment group also showed significantly lower levels of white blood cell count(WBC),neutrophil percentage,TNF-α,IL-6,HBP,and PCT compared to the control group(P < 0.05). Conclusion:The integrated treatment using Modified Liangge Powder for sepsis(syndrome of blazing heat-toxin)demonstrates good clinical efficacy.更多还原