【摘要】 目的 系统分析2012—2022年针灸治疗心肌缺血再灌注损伤(myocardial ischemia reperfusion injury, MIRI)的动物实验研究情况,为今后的实验研究提供参考。方法 查阅2012年1月1日—2022年6月1日中国知网、维普、万方、CBM、PubMed和Web of Science数据库发表的文献,对纳入文献的实验动物、造模方法、干预方案、对照组措施和结局指标等信息进行总结分析。结果 共纳入164篇文献,文献研究所用实验动物有大鼠、小鼠和兔子;干预措施涉及电针(n=149)、艾灸(n=16)等,电针治疗中有81篇针刺单穴内关,31篇针刺内关相关配穴,频率以2/100 Hz、2 Hz为多,刺激强度主要为1 m A,治疗时间以20 min为多;结局指标涉及形态学、功能学及分子生物学。结论 目前的研究肯定了针灸治疗MIRI的效果,在今后的研究中建议多关注实验动物选择、穴位配伍、针灸干预方案、干预手段联合作用效果的比较,注重对作用机制和临床应用的探索,最终指导临床提高临床疗效。更多还原

【Abstract】 Objective To make systematic review on the effect of animal experiment of acupuncture and moxibustion on myocardial ischemia reperfusion injury(MIRI) in 2012—2022 and provide reference for future experimental research.Methods Searched for CNKI, Wanfang, VIP, CBM, PubMed and Web of Science database from January 1, 2012 to June 1, 2022, and the experimental animals, modeling method, intervention group measures, control group measures and outcome indicators in the included literature were analyzed and summarized. Results A total of 164 literatures were included. The experimental animals included rats, mice and rabbits. The intervention measures involved electroacupuncture(n= 149) and moxibustion(n= 16). In the electroacupuncture treatment, 81 articles selected needle Neiguan single acupoint and 31 articles selected needle acupoints related to Neiguan. The frequency was mainly 2/100 Hz,2 Hz. The stimulation intensity was mainly 1 m A, and the treatment time was more than 20 minutes. The outcome indicators involved morphological indicators, functional indicators and molecular biological indicators. Conclusion The effect of acupuncture and moxibustion on MIRI is significant. It is recommended to pay more attention to the selection of experimental animals, the compatibility of acupoint, the intervention plan of acupuncture and moxibustion, and the effect of different combined of intervention means. Emphasis is placed to the research on the mechanism and clinical application, so as to guide clinical practice and improve clinical efficacy.更多还原