【摘要】 高迁移率族蛋白1(high mobility group box1,HMGB1)是一种高度保守的非组蛋白染色体结合蛋白。在生理条件下，HMGB1参与核内DNA的转录、复制、修复、重组和核小体形成。在病理条件下，大量释放到细胞外的HMGB1作为重要的炎症介质启动和维持炎症反应。HMGB1已被证实与脓毒症、创伤性损伤、自身免疫性疾病以及缺血/再灌注损伤等多种疾病的发病机制密切相关。甘草酸(glycyrrhizic acid)是大量存在于甘草的根和根茎中的一种天然三萜皂苷，具有多种药理功能。研究发现甘草酸作为天然的HMGB1抑制剂，通过与HMGB1结合进而阻断HMGB1与其受体的相互作用从而发挥抗炎活性。本文综述近年来甘草酸及其衍生物治疗HMGB1相关炎症性疾病的药理作用研究，为甘草酸及其衍生物的进一步临床应用提供实验基础。更多还原

【Abstract】 High-mobility group protein box1(HMGB1) is a highly conserved nuclear nonhistone chromosome interacting protein. Under physiological conditions, HMGB1 plays important roles in the modulation of DNA transcription, replication, repair, recombination, and nucleosome formation. In pathological state, excessive quantities of extracellular HMGB1 exerts cytokine-like effects and mediates inflammatory response. HMGB1 has been reported to be involved in a variety of inflammatory pathologies including sepsis, ischemia reperfusion injury, traumatic injury, immune disorders and so on. Glycyrrhizic acid(GL) is a triterpene saponin isolated from the roots and rhizomes of Glycyrrhiza spp. Increasing studies have demonstrated that GL exhibited multifaceted pharmacological functions. Recent studies showed that GL displayed anti-inflammatory activities via binding directly to HMGB1 and inhibiting the interaction of extracellular HMGB1 with its receptors. Here we summarize the therapeutic potential of GL and its derivatives in HMGB1-mediated inflammatory diseases, which would provide considerable experimental foundation for future clinical application of GL.更多还原