【摘要】 奥沙利铂(oxaliplatin, OXA)为第3代铂类抗癌药，广泛应用于中晚期结直肠癌、肝癌及胃癌等的治疗，但可引起肝脏微血管病变等副作用。本文报道1例奥沙利铂引起的非肝硬化门静脉高压患者，经过肝组织病理诊断为门静脉肝窦血管病，并通过中西医结合诊治，患者临床症状与食管胃底静脉曲张得到缓解；此外，文献回顾了OXA引起门静脉肝窦血管病等肝脏微血管病变的特点。更多还原

【Abstract】 Oxaliplatin(OXA) is a third-generation platinum-based anticancer drug, which is widely used in the treatment of colorectal cancer, liver cancer and gastric cancer. However, its use can lead to several side effects, including hepatic microvascular damage. This paper reports a case of non-cirrhotic portal hypertension caused by OXA, which was diagnosed as porto-sinusoidal vascular disease by liver histopathology. The patient was successfully treated with a combination of traditional Chinese medicine and Western medicine, leading to significant clinical improvement and alleviation of esophageal and gastric varices. In addition, the literature reviewed the characteristics of hepatic microvascular disease caused by OXA.更多还原