【摘要】 目的:探讨八宝丹胶囊对肝癌切除术后肝功能的保护作用。方法:40名肝癌切除术后患者随机分为八宝丹组和对照组，八宝丹组患者从术后第1天开始给予口服八宝丹胶囊，观察两组患者体温、血常规、凝血功能、肝功能、胸腹水、ECOG评分、术后住院天数以及住院总费用等变化。结果:八宝丹组患者在术后总胆红素(第7天及峰值)、直接胆红素(第7天及峰值)、谷丙转氨酶(第7天)、谷草转氨酶(第7天)、体温(第7天)、白细胞(第7天)、中性粒细胞百分比(第7天)、白蛋白(第7天及谷值)、中大量胸水发生率、术后住院天数以及住院总费用等均较对照组显著降低(P<0.05),中大量腹水发生率、凝血酶原时间、凝血酶原活动度和术后第7天ECOG评分是否恢复0-1分评价则两组未见显著性差异(P>0.05)。结论:八宝丹胶囊可促进肝切除术后肝脏解毒代谢功能恢复及减轻肝细胞术后损伤，其作用机制可能与抑制肝脏术后急性炎症反应有关，而对肝脏合成功能以及凝血系统功能可能无直接影响。更多还原

【Abstract】 Objective:To investigate the protective effect of Babao Dan on liver function after resection.Methods:Forty patients after hepatectomy were randomly divided into the Babaodan group and the control group and were given oral Babaodan capsules and blank control observation from the first postoperative day, respectively.Results:Total bilirubin(day seven and peak), direct bilirubin(day seven and peak), ghrelin(day seven), ghrelin(day seven), body temperature(day seven), white blood cells(day seven), neutrophil percentage(day seven), albumin(day seven and trough), the incidence of moderate to massive pleural fluid, postoperative hospitalization days and total hospitalization cost were significantly lower in the octopod group compared with the control group were significantly lower(P<0.05). The incidence of moderate and large amounts of ascites, prothrombin time, prothrombin activity, and whether the ECOG score returned to 0-1 on postoperative day seven were not significantly different between the two groups(P>0.05).Conclusion:Babaodan can promote the recovery of hepatic detoxification and metabolic function after hepatectomy and reduce the postoperative damage of hepatocytes. Its mechanism of action may be related to the inhibition of acute inflammatory response in the liver after hepatectomy, while it may have no direct effect on hepatic synthetic function and coagulation system function.更多还原