【摘要】 目的 探讨经胸超声心动图联合超声造影检测冠状动脉血流储备(CFR)对高血压患者冠状动脉病变的预测价值。方法 纳入伴有左心室肥厚(LVH)的高血压患者45例作为观察组,另纳入45例单纯高血压患者作为对照组。对所有患者开展经胸超声心动图联合超声造影检查,比较两组经胸超声心动图检查结果及造影检查结果。结果 两组患者的静息舒张期峰值血流速度(PDV)比较无差异(P>0.05)；观察组的负荷PDV(47.34±14.98)cm/s及CFR(1.94±0.78)低于对照组的(67.78±15.57)cm/s、(2.83±1.82)(P<0.05)。观察组灌注量(7.02±2.91)L/min、曲线峰值强度(9.46±7.62)dB、曲线斜率(1.23±1.03)dB/s低于对照组的(9.64±3.34)L/min、(16.78±8.43)dB、(1.78±1.22)dB/s,灌注阳性率71.11%高于对照组的22.22%(P<0.05)。结论 经胸超声心动图联合超声造影可实现对CFR的评估,帮助了解高血压患者的冠状动脉病变情况,为冠状动脉病变的防治提供依据。更多还原

【Abstract】 Objective To explore the predictive value of transthoracic echocardiography combined with contrast-enhanced ultrasound in detection of coronary flow reserve(CFR) for coronary artery disease in hypertensive patients. Methods 45 patients with hypertension accompanied by left ventricular hypertrophy were included in the observation group, and another 45 patients with simple hypertension were included in the control group. Transthoracic echocardiography combined with contra-enhanced ultrasound was performed in patients to compare the transthoracic echocardiographic findings and contrast-enhanced findings between the two groups.Results There was no difference in resting peak diastolic velocity(PDV) between the two groups(P>0.05).The observation group had load PDV of(47.34±14.98) cm/s and CFR of(1.94±0.78), which were lower than(67.78±15.57) cm/s and(2.83±1.82) of the control group(P<0.05). In the observation group, the perfusion volume was(7.02±2.91) L/min, the peak curve intensity was(9.46±7.62) dB, and the curve slope was(1.23±1.03) dB/s, which were lower than(9.64±3.34) L/min,(16.78±8.43) dB, and(1.78±1.22) dB/s in the control group; the positive rate of perfusion of 71.11% was higher than 22.22% in the control group(P<0.05). Conclusion Transthoracic echocardiography combined with contrast-enhanced ultrasound can realize the evaluation of CFR,help to understand the coronary artery disease in hypertensive patients, and provide evidence for the prevention and treatment of coronary artery disease.更多还原