【摘要】 目的 分析醋酸曲安奈德软膏联合3M液体敷料在治疗新生儿尿布皮炎中的临床价值。方法 遴选被确诊为尿布皮炎的80例新生儿为研究对象,按照随机数字表法分为联合组(40例)与单药组(40例)。联合组联合应用醋酸曲安奈德软膏与3M液体敷料治疗,单药组单纯使用醋酸曲安奈德乳膏治疗。比较两组新生儿临床效果、不良事件发生情况及治疗前后皮炎分度、皮损面积评分。结果 联合组治疗总有效率为95.00%(38/40),高于单药组的80.00%(32/40)(P<0.05)。治疗后,联合组新生儿的皮炎分度显著优于单药组(P<0.05)。治疗后,两组新生儿的皮损面积评分均低于治疗前,且联合组新生儿的皮损面积评分(0.21±0.05)分显著低于单药组的(0.68±0.12)分(P<0.05)。联合组新生儿出现潮红加重1例,不良事件发生率为2.50%；单药组出现皮肤糜烂1例,潮红加重2例,不良事件发生率为7.50%。两组不良事件发生率比较差异无显著性(P>0.05)。结论 新生儿尿布皮炎联合应用醋酸曲安奈德乳膏和3M液体敷料的临床效果肯定,有助于缓解患儿皮炎症状,加速康复进程,且治疗安全性较好。更多还原

【Abstract】 Objective To analyze the clinical value of triamcinolone acetonide acetate ointment combined with 3M liquid dressing in the treatment of neonatal diaper dermatitis. Methods 80 neonates diagnosed with diaper dermatitis were selected as the research subjects. According to the random number table method, they were divided into a combination group(40 cases) and single drug group(40 cases). The combination group was treated with triamcinolone acetonide acetate ointment and 3M liquid dressing, and the single drug group was treated with triamcinolone acetonide acetate ointment. The clinical effect, adverse events, dermatitis grading and skin lesion score before and after the treatment were compared between the two groups. Results The total effective rate of the combination group was 95.00%(38/40), which was higher than the single drug group’s 80.00%(32/40)(P<0.05). After treatment, the neonatal dermatitis grading in the combination group was significantly better than that in single drug group(P<0.05). After treatment, the skin area score in both groups was lower than that before treatment, and the skin area score of(0.21±0.05) points in the combination group was significantly lower than(0.68±0.12) points in the single drug group(P<0.05). In the combination group, there was 1 case of aggravated flushing, and the incidence of adverse events was 2.50%. In the single drug group, there were 1 case of skin erosion, 2 cases of aggravated flushing, and the incidence of adverse events was 7.50%. There was no significant difference in the incidence of adverse events between the two groups(P>0.05). Conclusion The combination of triamcinolone acetonide acetate ointment and 3M liquid dressing has a positive clinical effect in the treatment of neonatal diaper dermatitis, which can relieve the symptoms of dermatitis and accelerate the recovery process, with a good safety profile.更多还原