【摘要】 目的 分析上消化道出血应用生长抑素联合奥美拉唑的治疗效果及安全性。方法 70例上消化道出血患者,以随机数字表法分为参照组和观察组,各35例。参照组患者以奥美拉唑开展治疗,观察组患者以奥美拉唑+生长抑素开展治疗。对比两组治疗效果、不良反应发生情况、止血时间和住院时间及治疗前后凝血功能[D-二聚体(D-D)、血浆纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)]。结果 观察组总有效率97.14%高于参照组的80.00%(P<0.05)。观察组止血时间(12.32±3.36)h、住院时间(7.18±1.74)d短于参照组的(18.23±5.32)h、(10.13±2.23)d(P<0.05)。观察组不良反应发生率2.86%低于参照组的17.14%(P<0.05)。治疗后,观察组D-D(0.53±0.22)mg/L、APTT(26.03±2.12)s、PT(11.13±0.58)s低于参照组的(0.96±0.39)mg/L、(28.42±3.11)s、(13.68±0.68)s,FIB(2.93±0.29)g/L高于参照组的(2.21±0.32)g/L(P<0.05)。结论 上消化道出血应用生长抑素联合奥美拉唑治疗效果显著,可有效改善机体的凝血功能,减少出血量,缩短住院时间,并且用药后不良反应较少,安全性较高,值得推广。更多还原

【Abstract】 Objective To analyze the effect and safety of somatostatin combined with omeprazole in the treatment of upper gastrointestinal hemorrhage. Methods 70 patients with upper gastrointestinal hemorrhage were divided into a reference group and an observation group by random number table method, with 35 cases in each group. The reference group was treated with omeprazole, and the observation group was treated with omeprazole +somatostatin. Both groups were compared in terms of treatment effect, occurrence of adverse reactions, time to hemostasis, length of hospital stay, and coagulation function [D-dimer(D-D), plasma fibrinogen(FIB), activated partial thromboplastin time(APTT), plasma prothrombin time(PT)] before and after treatment. Results The total effective rate of 97.14% in the observation group was higher than 80.00% in the reference group(P<0.05). The time to hemostasis and length of hospital stay of the observation group were(12.32±3.36) h and(7.18±1.74) d, which were shorter than(18.23±5.32) h and(10.13±2.23) d of the reference group(P<0.05). The incidence of adverse reactions of 2.86% in the observation group was lower than 17.14% in the reference group(P<0.05). After treatment,the observation group had D-D of(0.53±0.22) mg/L, APTT of(26.03±2.12) s, and PT of(11.13±0.58) s,which were lower than(0.96±0.39) mg/L,(28.42±3.11) s, and(13.68±0.68) s in the reference group; the observation group had higher FIB of(2.93±0.29) g/L than(2.21±0.32) g/L in the reference group(P<0.05).Conclusion The application of somatostatin combined with omeprazole in the treatment of upper gastrointestinal hemorrhage has significant effects, which can effectively improve the body’s coagulation function, reduce the amount of blood loss, shorten the length of hospital stay, and have fewer adverse reactions after medication. It is safe and worthy of promotion.更多还原