【摘要】 目的 探讨糖尿病（DM）对慢性阻塞性肺疾病（COPD）患者肺功能及血气分析的影响。方法 选取30例单纯COPD患者为甲组,并选择同期30例糖尿病病程低于10年的COPD患者为乙组,糖尿病病程高于10年的COPD患者为丙组,监测所有患者肺功能和血气分析指标。对比三组血气分析指标[动脉血二氧化碳分压（Pa CO₂）、动脉血氧分压（Pa O₂）],肺功能指标[第1秒用力呼气容积（FEV1）占预计值的百分比、FEV1/用力肺活量（FVC）、用力呼气中段流量(FEF_25%～75%)、FVC占预计值的百分比、单位肺泡一氧化碳弥散量（DLCO/VA）、肺一氧化碳弥散量（DLCO）]。结果 两两组间Pa CO₂对比未见明显差异（P>0.05）；乙组、丙组Pa O₂分别为（63.29±5.18）、（51.18±11.15）mm Hg（1 mm Hg=0.133 k Pa）,比甲组的（68.43±10.32）mm Hg低,且丙组低于乙组（P<0.05）。两两组间FEV1占预计值的百分比、FEV1/FVC、FEF_25%～75%对比未见显著差异（P>0.05）；甲组、乙组、丙组FVC占预计值的百分比分别为（76.32±9.34）%、（69.14±8.23）%、（61.35±10.78）%；甲组、乙组、丙组DLCO/VA分别为（3.56±0.89）、（3.12±0.73）、（2.51±0.67）ml/（mm Hg·min·L）；甲组、乙组、丙组DLCO分别为（18.41±2.69）、（17.76±1.87）、（16.34±1.23）ml/（mm Hg·min）。两两组间FVC占预计值的百分比、DLCO/VA对比,差异有统计学意义（P<0.05）。甲组与乙组DLCO对比,差异无统计学意义（P<0.05）。丙组DLCO比甲组、乙组均较低（P<0.05）。结论 糖尿病病程超过10年的糖尿病患者弥散功能及肺功能等越来越低,临床应根据患者血气指标及肺功能等实际情况采取针对性治疗方法,以便其身体功能得到有效改善,促进患者生活质量的提高。更多还原

【Abstract】 Objective To explore the effects of diabetes mellitus （DM） on pulmonary function and blood gas analysis in patients with chronic obstructive pulmonary disease （COPD）.Methods 30 patients with simple COPD were selected as group A,and concurrent 30 COPD patients with course of diabetes less than 10 years were selected as group B,and 30 COPD patients with course of diabetes more than 10 years were selected as group C.The pulmonary function and blood gas analysis indicators of all patients were monitored.Comparison was made on blood gas analysis indicators[arterial partial pressure of carbon dioxide （Pa CO₂） and arterial partial pressure of oxygen （Pa O₂）],pulmonary function indicators[forced expiratory volume in one second （FEV1）as a percentage to the predicted value,FEV1/forced vital capacity （FVC）,mid-expiratory flow (FEF_25%-75%),forced vital capacity （FVC） as a percentage to the predicted value,diffusing lung capacity of carbon monoxide/alveolar volume （DLCO/VA）,diffusing lung capacity of carbon monoxide （DLCO）]among the three groups.Results There was no significant difference in Pa CO₂ between every two groups （P>0.05）.The Pa O₂ in group B and group C were （63.29±5.18） and （51.18±11.15） mm Hg （1 mm Hg=0.133 k Pa）,which was lower than（68.43±10.32） mm Hg in group A,and the PAO₂ in group C was lower than that in group B （P<0.05）.There were no significant differences in FEV1 as a percentage to the predicted value,FEV1/FVC,and FEF_25%-75%between every two groups （P>0.05）.The FVC as a percentage to the predicted value in group A,group B and group C were（76.32±9.34）%,（69.14±8.23）%and （61.35±10.78）%,respectively.The DLCO/VA of group A,group B and group C were （3.56±0.89）,（3.12±0.73） and （2.51±0.67） ml/（mm Hg·min·L）,respectively.The DLCO of group A,group B and group C were （18.41±2.69）,（17.76±1.87） and （16.34±1.23） ml/（mm Hg·min）,respectively.There were significant differences in FVC as a percentage to the predicted value and DLCO/VA between every two groups （P<0.05）.There was no significant difference in DLCO between group A and group B （P<0.05）.The DLCO of group C was lower than that of group A and group B （P<0.05）.Conclusion The diffusion function and lung function of diabetes mellitus patients with course of diabetes more than 10 years are getting lower and lower,and targeted treatment should be taken according to the actual situation of patients’blood gas index and pulmonary function,so as to effectively improve their body function and promote the improvement of patients’quality of life.更多还原