【摘要】 由细菌耐药性引起的干预疗效不佳或治疗失败正不断挑战人类和动物健康。研究如何科学合理使用抗菌药物治疗和有效评估宿主体内抗菌药物疗效具有重要意义。本综述总结抗菌药物体内疗效评估方法并分析其不足之处，提出新的思考与探索，旨在为科学、合理、有效使用抗菌药物提供参考，减少耐药性产生，最大程度降低干预疗效不佳或治疗失败引起的影响。更多还原

【Abstract】 Interventional inefficacy or treatment failure caused by bacterial resistance continues to challenge human and animal health. It is of great significance to study how to use antimicrobial agents scientifically and rationally for treatment and to evaluate the efficacy of antimicrobial agents in the host effectively. This review summarizes the methods for evaluating the in vivo efficacy of antimicrobial agents, analyzes their shortcomings, and proposes new considerations and explorations, aiming to provide references for the scientific, rational, and effective use of antimicrobial agents, reduce the emergence of resistance, and minimize the impact of interventional inefficacy or treatment failure.更多还原