【摘要】 运动功能障碍是脑卒中后的主要症状，一般认为是由控制运动功能的神经网络的损伤引起的。为了探讨卒中患者的神经肌肉控制机制，本研究以皮层肌肉功能连接(FCMC)为工具，采集13例卒中患者和13例健康对照者前伸动作时的脑电信号(EEG)及肱三头肌、前三角肌前束、中束、后束、肱二头肌、胸大肌、斜方肌的肌电信号(EMG)。通过脑源定位得到大脑皮层源信号，再聚类确定动作对应的活跃脑区，使用偏传递熵求取皮层肌肉功能连接。卒中患者ICsF与AD、ICsB与BIC、ICsC与PD、PM、UT在上行通道的功能连接与健康对照组相比显著增强(例如健康对照组为0.033±0.031,卒中患者为0.092±0.083,P<0.05);卒中患者BIC与ICsA、ICsB、ICsC,TRI、UT与ICsC在下行通道的功能连接与健康对照组相比显著增强(例如健康对照组为0.113±0.092,卒中患者为0.198±0.105,P<0.05);卒中患者存在同侧的皮层肌肉功能连接。实验结果表明，该研究从新的角度探索脑卒中后皮层肌肉功能连接效应，证明了卒中患者存在同侧的皮层肌肉功能连接，进一步有效促进对卒中后神经肌肉耦合机制的理解。更多还原

【Abstract】 Motor dysfunction is the main symptom after stroke, which is generally thought to be caused by the damage of neural network that controls motor function. To explore the neuromuscular control mechanism of stroke patients, in this paper, the functional cortical muscular coupling(FCMC) is used as a tool to collect the electroencephalogram(EEG) signals of 13 stroke patients and 13 healthy controls during the extension movement. Meanwhile, the Electromyogram(EMG) signals of triceps brachii, anterior deltoid toe, middle toe, back toe, biceps brachii, pectoralis major and trapezius muscle are obtained by FCMC. Moreover, by locating the cerebral cortex source, the raw EEG signal is obtained, afterwards the active brain region corresponding to the action is also determined by clustering, finally the cortical muscle functional connection is obtained by using partial transfer entropy. The functional connectivity of ICsF with AD, ICsB with BIC, ICsC with PD, PM, and UT in the upstream channels was significantly enhanced in stroke patients compared with healthy controls(For example, the healthy control group is 0.033±0.031, the stroke patient is 0.092±0.083, P<0.05). The functional connectivity of BIC with ICsA, ICsB and ICsC, TRI and UT with ICsC in the downstream channels was significantly enhanced in stroke patients compared with healthy controls(For example, the healthy control group is 0.113±0.092, and the stroke patients are 0.198±0.105, P<0.05). Ipsilateral cortical muscle functional connectivity is present in stroke patients. The experimental results show that this paper explores the cortical muscle functional connection effect after stroke from a new angle, and proves that there exists ipsilateral cortical muscle functional connection in stroke patients, which further effectively promotes the understanding of neuromuscular coupling mechanism after stroke.更多还原