【摘要】 目的 探讨血浆D-二聚体检测在食管癌诊断中的应用价值。方法 选取60例接受手术治疗的食管癌患者作为食管癌组,术前及术后第1、14天检测血浆D-二聚体水平；另选取60例健康体检者作为对照组,体检时检测血浆D-二聚体水平。比较食管癌组术前与对照组D-二聚体水平及D-二聚体阳性率；比较食管癌组患者术前与术后D-二聚体水平；比较食管癌组不同临床特征患者术前D-二聚体水平及D-二聚体阳性率。结果 食管癌组术前D-二聚体水平为(0.65±0.25)mg/L,显著高于对照组的(0.32±0.16)mg/L(P<0.05)；食管癌组术前D-二聚体阳性率35.00%(21/60)显著高于对照组的15.00%(9/60)(P<0.05)。食管癌组术后第1天D-二聚体水平为(1.21±0.49)mg/L,显著高于术前的(0.65±0.25)mg/L(P<0.05)；食管癌组术后第14天D-二聚体水平为(0.35±0.15)mg/L,显著低于术前的(0.65±0.25)mg/L(P<0.05)。食管癌组不同性别(男性、女性)、年龄(<70岁、≥70岁)、肿瘤部位(胸上段、胸中段、胸下段及食管胃交界部)患者术前D-二聚体水平比较无差异(P>0.05)；食管癌组不同分化程度及术后病理分期患者术前D-二聚体水平比较差异有统计学意义(P<0.05)。食管癌组不同性别(男性、女性)、年龄(<70岁、≥70岁)、肿瘤部位(胸上段、胸中段、胸下段及食管胃交界部)患者术前D-二聚体阳性率比较无差异(P>0.05)；食管癌组不同分化程度及术后病理分期患者术前D-二聚体阳性率比较差异有统计学意义(P<0.05)。结论 血浆D-二聚体检测对食管癌的诊断具有一定的应用价值。更多还原

【Abstract】 Objective To explore the application value of detection of plasma D-dimer in the diagnosis of esophageal cancer. Methods A total of 60 esophageal cancer patients who underwent surgical treatment were selected as the esophageal cancer group. The plasma D-dimer level was detected before operation, on the 1st day after operation, and on the 14th day after operation. Another 60 healthy subjects were selected as the control group, and plasma D-dimer levels were detected during physical examination. Comparison was made on D-dimer level and D-dimer positivity rate between the esophageal cancer group before treatment and the control group,D-dimer levels preoperatively and postoperatively in the esophageal cancer group, as well as D-dimer levels and D-dimer positivity rate of patients with different clinical features in the esophageal cancer group. Results The preoperative D-dimer level in the esophageal cancer group was(0.65±0.25) mg/L, which was significantly higher than(0.32±0.16) mg/L in the control group(P<0.05); the preoperative D-dimer positivity rate in the esophageal cancer group was 35.00%(21/60), which was significantly higher than 15.00%(9/60) in the control group(P<0.05).The D-dimer level in the esophageal cancer group was(1.21±0.49) mg/L on the 1st day after operation, which was significantly higher than(0.65±0.25) mg/L before operation(P<0.05). The D-dimer level was(0.35±0.15) mg/L in the esophageal cancer group on the 14th day after operation, which was significantly lower than(0.65±0.25) mg/L before operation(P<0.05). In the esophageal cancer group, there were no differences in preoperative D-dimer level among patients with different sex(male and female), age(<70 years old, ≥70 years old) and tumor site(upper thoracic segment, middle thoracic segment, lower thoracic segment and esophagogastric junction)(P>0.05). The difference in preoperative D-dimer levels of patients with different degree of differentiation and postoperative pathological stages in the esophageal cancer group was statistically significant(P<0.05). In the esophageal cancer group, there were no differences in preoperative D-dimer positivity rate among patients with different sex(male and female), age(<70 years old, ≥70 years old) and tumor site(upper thoracic segment, middle thoracic segment,lower thoracic segment and esophagogastric junction)(P>0.05). The difference in preoperative D-dimer positivity rate of patients with different differentiation and postoperative pathological stages in the esophageal cancer group was statistically significant(P<0.05). Conclusion The detection of plasma D-dimer level has certain practical value in the diagnosis of esophageal cancer.更多还原