【摘要】 目的 探索不同年龄阶段抑郁障碍患者非酶抗氧化物水平的差异。方法 纳入抑郁障碍患者135例（包括年龄≥60岁的老年抑郁组63例和<60岁的中青年抑郁组72例），健康对照98名（包括年龄≥60岁的老年对照组46名和<60岁的中青年对照组52名）。测定被试血清非酶抗氧化物尿酸、总胆红素和白蛋白水平。结果 双因素方差分析表明，对于尿酸、总胆红素水平，抑郁因素主效应均有统计学意义（P<0.05），抑郁障碍患者的尿酸[（314.30±85.18）μmol/L vs.(339.68±85.27)μmol/L]、总胆红素[（12.81±6.16）μmol/L vs.(15.09±5.97)μmol/L]水平低于对照（P<0.05）。年龄分组与抑郁因素对白蛋白水平的影响存在交互作用（F=11.059, P<0.001），老年抑郁组患者的白蛋白[（41.05±3.97）g/L vs.(46.01±4.49)g/L]水平低于中青年抑郁组患者（P<0.01）。结论 抑郁障碍患者存在非酶类抗氧化物的异常，老年患者的损害更为突出。更多还原

【Abstract】 Objective This study aimed to investigate the levels of non-enzymatic antioxidants among patients with depression at different age stages. Methods One hundred thirty five patients with depression(including 63 elderly patients aged 60 years and older, and 72 young and middle-aged patients under 60 years old) and 98 healthy controls(including 46 elderly controls aged 60 years and older, and 52 young and middle-aged controls aged under 60 years old)were enrolled. Serum levels of non-enzymatic antioxidants(uric acid, total bilirubin, albumin) were assessed. Results Multiple analysis of variance showed the main effects of depression factors on uric acid and total bilirubin were significant(P<0.05). Uric acid [(314.30±85.18) μmol/L vs.(339.68±85.27) μmol/L], total bilirubin [(12.81±6.16) μmol/L vs.(15.09±5.97) μmol/L] levels were lower in patients with depression than in controls(P<0.05). There was an interactive effect between age and depression factors on the levels of albumin(P<0.001), and the levels of albumin [(41.05±3.97) g/L vs.(46.01±4.49) g/L] were lower in group of the elderly patients with depression than those in group of the young and middle-aged patients with depression(P<0.01). Conclusion Patients with depression have abnormalities in levels of non-enzymatic antioxidants which are more severe in elderly patients.更多还原