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激活转录因子ATF7生物学功能的研究进展
Advances in biological function of activating transcription factor ATF7
【摘要】 激活转录因子7(ATF7)是一种应激诱导的转录因子,属于激活转录因子/环磷腺苷效应元件结合蛋白(CREB)家族中的一员,通常在应激状态下被磷酸化,从而激活靶基因的转录,调节相关的生物学过程。基于现有文献报道,本文综述了ATF7在调节免疫、肿瘤、代谢等生物学过程中的作用,为后续进一步研究提供理论基础。
【Abstract】 Activating transcription factor 7(ATF7) is a stress-induced transcription factor, a member of the cAMP-response element binding protein(CREB) family, which is usually phosphorylated under stress to activate the transcription of target genes and regulate related biological processes. Based on the existing literature reports, we reviewed the role of ATF7 in regulating immunity, tumor and metabolism, which provides a theoretical basis for further research.
【关键词】 激活转录因子7;
先天免疫;
肿瘤免疫;
衰老;
细胞周期;
【Key words】 Activating transcription factor 7; Innate immunity; Tumor immunity; Aging; Cell cycle;
【Key words】 Activating transcription factor 7; Innate immunity; Tumor immunity; Aging; Cell cycle;
【基金】 国家重点研发计划(2021YFC2300801);国家自然科学基金(81802036,81871682);广东省自然科学基金(2023A1515030050,2020A1515010896);中国博士后科学基金(2019T120770,2018M631027)
- 【文献出处】 中国免疫学杂志 ,Chinese Journal of Immunology , 编辑部邮箱 ,2024年12期
- 【分类号】R392
- 【下载频次】72