【摘要】 IL-33是IL-1细胞因子超家族的成员，是机体病理性炎症、免疫稳态和纤维化过程中的关键调节剂。IL-33受体ST2在固有免疫细胞表面均有表达，在B细胞和T细胞的部分亚型表面也有所表达。IL-33是一种双重功能蛋白。正常情况下，IL-33的N端部分驻留在其表达细胞的细胞核中，当细胞发生损伤或坏死时作为细胞因子释放到细胞外发挥免疫调节特性。IL-33不同表达形式的细胞定位不同，可能发挥的免疫学作用也不相同。IL-33的免疫学作用具有很强的多样性，细胞因子IL-33在固有免疫应答中起放大增强的作用，而细胞核内储存的全长型（FL）IL-33通过结合抑制NF-κB发挥抑制炎症的作用。IL-33/ST2轴在先天性和获得性免疫反应中都起着关键作用。在先天免疫中，IL-33和第2组先天淋巴细胞（ILC2）为快速免疫应答和组织稳态提供了一个重要的轴。在获得性免疫中，IL-33与树突状细胞、Th2细胞、滤泡辅助性T细胞（Tfh）和调节性T细胞（Tregs）相互作用。IL-33/ST2信号传导以自分泌和旁分泌方式触发不同细胞类型的促肿瘤免疫反应或抗肿瘤免疫反应。此外IL-33和细胞代谢之间的相互作用也是影响免疫系统的潜在机制之一。更多还原

【Abstract】 IL-33 is a member of the IL-1 cytokine superfamily. It is a key regulator of pathological inflammation, immune homeostasis and fibrosis. IL-33 receptor ST2 is expressed on the surface of all innate immune cells, as well as some subtypes of B and T cells. IL-33 is a dual-function protein. Under normal circumstances, the N-terminal part of IL-33 resides in the nucleus of its expressed cells and is released as a cytokine to exert immunomodulatory properties when cells are damaged or necrotic. Different expression forms of IL-33 are located differently and may play different immunological roles. The immunological effects of IL-33 are highly diverse. The cytokine IL-33 plays an amplifying and enhancing role in the innate immune response, while the full-length(FL)IL-33stored in the nucleus inhibits inflammation by binding to NF-κB. IL-33/ST2 signaling plays a key role in both innate and acquired immune responses. In innate immunity, IL-33 and group 2 innate lymphocytes(ILC2) provide an important axis for rapid immune response and tissue homeostasis. In acquired immunity, IL-33 interacts with dendritic cells, Th2 cells, follicular helper T cells(Tfh) and regulatory T cells(Tregs). IL-33/ST2 signaling triggers pro-tumor or anti-tumor immune responses in different cell types in autocrine and paracrine ways. In addition, the interaction between IL-33 and mitochondrial metabolism is also one of the potential mechanisms affecting the immune system.更多还原