【摘要】 目的 了解1990—2019年浙江省抑郁障碍疾病负担和危险因素变化趋势，为该省抑郁障碍防控工作提供科学依据。方法 数据源于2019年全球疾病负担研究（GBD 2019），采用使用Excel 2016描述1990—2019年浙江省抑郁障碍发病率、患病率和伤残调整寿命年（DALY）率和主要危险因素归因DALY率的变化趋势，同时与全国、世界不同社会人口学指数（SDI）地区进行比较。采用Joinpoint Regression Program 5.0.1软件计算平均年度变化百分比（AAPC）。结果 2019年浙江省抑郁障碍发病率、患病率和DALY率分别为3 726.65/10万、4 253.14/10万和664.38/10万，其中70岁及以上人群组最高，0～14岁组最低。2019年浙江省女性抑郁障碍发病率、患病率和DALY率均高于男性。1990—2019年浙江省抑郁障碍发病率、患病率和DALY率总体均呈上升趋势（AAPC分别为0.32%、0.69%和0.49%,P<0.05），且始终高于中国平均水平和中SDI地区。1990—2019年浙江省抑郁障碍前3名危险因素排序为亲密伴侣暴力、欺凌受害和儿童期性虐待，3种危险因素的标化DALY率均呈下降趋势（AAPC分别为-0.77%、-1.13%和-0.42%,P<0.05）。结论 1990—2019年浙江省抑郁障碍疾病负担总体呈现上升趋势。应根据现阶段抑郁障碍疾病负担特点，制定差异化和精细化防治措施，降低浙江省抑郁障碍疾病负担。更多还原

【Abstract】 Objective To understand the trend of disease burden and risk factors of depressive disorders in Zhejiang Province from1990 to 2019,and provide the scientific basis for the prevention and control of depressive disorders in Zhejiang Province. Methods The data were from 2019 Global Burden of Disease Study(GBD2019);trends in the incidence,prevalence,and disability-adjusted life years(DALY) rates and major risk factors attributed to the DALY rate in Zhejiang Province from 1990 to 2019 were calculated;and those were compared to the regions with different socio-demographic index(SDI) of China and the world. Joinpoint Regression Program 5.0.1 software was used to calculate the average annual percent change(AAPC). Results In 2019,incidence,morbidity and DALY rate were 3 726.65/105,4 253.14/105and 664.38/105,respectively;in which,those of ≥70 years old group were the highest,those of 0-14 years old group were the lowest. In 2019,incidence,morbidity and DALY rate of females were higher than those of males. From 1990 to 2019,the incidence,morbidity and DALY rate of depressive disorders in Zhejiang Province showed the upward trend(AAPC values were 0.32%,0.69% and 0.49%,respectively);which were higher than mean levels in China and the levels in middle SDI regions. From 1990 to 2019,the order of top 3 risk factors were intimate partner violence,bullying victimization and childhood sexual abuse;the standardized DALY rates of three risk factors showed downward trend(AAPC values were-0.77%,-1.13% and-0.42%,respectively,P <0.05). Conclusion From 1990 to 2019,the disease burden of depressive disorders in Zhejiang Province showed upward trend. It should formulate the differentiated and refined prevention and control measures to reduce the burden of depression disorder in Zhejiang Province,according to the current disease burden characteristics of depressive disorder.更多还原