【摘要】 目的 评估吸烟者使用个性化戒烟干预APP（“帮你戒烟”）干预后的吸烟行为改变情况并探索戒烟行为影响因素，为后续该APP进行大范围推广应用提供参考。方法 采用随机对照试验设计，于2023年8—9月通过线上招募的方式招募有戒烟意愿的1 278名现在吸烟者，将其随机分成对照组（n=639）和干预组（n=639），干预组剔除未成功下载APP者后剩余517名。研究对象在线填写基线问卷，干预组研究对象使用“帮你戒烟”APP和电子自助戒烟手册进行干预，对照组仅使用电子自助戒烟手册进行干预。干预1个月后对研究对象的戒烟情况进行随访评估。采用SAS 9.4进行χ~2检验和log-binomial回归分析。结果 该研究采用意向性分析将失访研究对象视为现在吸烟者，结果显示，干预1个月后干预组戒烟率（18.76%）、尝试戒烟率（57.83%）和减烟率（13.35%）均高于对照组（分别为10.49%、46.32%和6.73%），差异均有统计学意义（P<0.01）。多因素log-binomial回归分析结果显示，干预组研究对象戒烟效果相对较好（RR=1.773,95%CI:1.336～2.369）；非在职（RR=0.655,95%CI:0.426～0.957）、超重或肥胖（RR=0.663,95%CI:0.499～0.885）、中度尼古丁依赖（RR=0.689,95%CI:0.472～0.980）和重度尼古丁依赖（RR=0.599,95%CI:0.425～0.832）的研究对象戒烟效果相对较差。结论 “帮你戒烟”APP可显著提高吸烟者尝试戒烟和短期戒烟率，建议考虑作为现有戒烟服务的补充。更多还原

【Abstract】 Objective To assess the smoking behaviour change of smokers after the intervention of using the personalized smoking cessation intervention APP( "Helping You Quit"),explore the factors influencing smoking cessation behaviour,and provide the reference for the APP expansion scope in future. Methods The randomized controlled trial design was used to recruit 1 278current smokers with quit smoking willingness through online recruitment from August to September in 2023 as the subjects. The subjects were randomly divided into the control group(n =639) and the intervention group(n =639),but there were only 517subjects in the intervention group after excluding the subjects without downloading the app successfully. The investigation was performed with questionnaire online. "Helping You Quit" APP and "Electronic self-help smoking cessation manual" were used in intervention group,only "Electronic self-help smoking cessation manual" was used in controlled group. After the intervention for one month,the smoking cessation was assessed. The χ~2test and log-binomial regression analysis were used to analyze the data. The used software was SAS 9.4. Results The results of intentionality(ITT) analysis showed that after intervention for one month,the smoking cessation rate,the attempted cessation rate and the smoking reduction rate of the subjects in the intervention group were18.76%,57.83% and 13.35%,which were significantly higher than those(10.49%,46.32% and 6.73%) in controlled group,P<0.01.The results of log-binomial regression analysis showed that the smoking cessation effect in the subjects of the intervention group was relatively better(RR =1.773,95% CI:1.336 ～2.369);the smoking cessation effects in the non-working staff(RR =0.655,95% CI:0.426-0.957),the subjects with overweight or obese(RR =0.663,95% CI:0.499-0.885),and the subjects with moderate nicotine dependence(RR=0.689,95%CI:0.472-0.980) and severe nicotine dependence(RR=0.599,95%CI:0.425-0.832) were relatively worse. Conclusion "Help You Quit" APP can significantly increase the quit attempts and short-term quit rates of smokers,and it should be considered as a supplement of current smoking cessation services.更多还原