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阻塞性睡眠呼吸暂停与心力衰竭相关性研究进展
Progress in research on obstructive sleep apnea and heart failure
【摘要】 随着老龄化的进程加快,阻塞性睡眠呼吸暂停(OSA)与心力衰竭(HF)的患病率呈明显升高趋势。研究表明,OSA与HF互为因果,相互影响。OSA是HF的独立危险因素,HF又会引起OSA,这会使HF的症状进展、住院和死亡等不良后果的风险增加。OSA与HF之间的相互作用与上气道阻塞和慢性间歇性低氧密不可分。对于OSA相关性HF,目前没有明晰的诊疗方案。针对两者的发病机制及症状,HF治疗药物通常推荐与OSA的一线治疗方法持续气道正压通气合并使用。本文对OSA与HF相关性研究的最新进展予以综述,旨在为后续更有效的针对性治疗提供必要的参考。
【Abstract】 With the acceleration of ageing process, the prevalence of obstructive sleep apnea(OSA) and heart failure(HF) has been significantly increasing. Studies show that OSA and HF are causal and mutually influential. OSA is an independent risk factor for HF, which in turn causes OSA, increasing the risk of adverse outcomes such as symptom progression, hospitalization, and death in HF. The interaction between OSA and HF is inextricably linked to upper airway obstruction and chronic intermittent hypoxia. Currently, there is no definitive diagnosis and treatment protocol for OSA-associated heart failure. Considering the pathogenesis and symptoms of both, HF treatment drugs are usually recommended to be combined with continuous positive airway pressure, the first-line treatment for OSA. In this article, we reviewed the research on OSA and HF to provide necessary references for subsequent more effective targeted treatment.
【Key words】 obstructive sleep apnea; heart failure; hypoxia; continuous positive airway pressure;
- 【文献出处】 中华老年多器官疾病杂志 ,Chinese Journal of Multiple Organ Diseases in the Elderly , 编辑部邮箱 ,2024年08期
- 【分类号】R766;R541.6
- 【下载频次】18