节点文献
中国肿瘤住院患者肌肉减少症调查报告
The prevalence of sarcopenia in hospitalized cancer patients in China
【摘要】 目的 报告中国恶性肿瘤患者肌肉减少症的流行病学调查结果。方法 纳入中国肿瘤营养队列研究常见恶性肿瘤营养状态与临床结局相关性研究(INSCOC)数据库2013年7月至2023年12月86家三级甲等医院19种恶性肿瘤患者61627例。采用亚洲肌肉减少症工作组(AWGS)2019年肌肉减少症诊断标准诊断肿瘤患者肌肉减少症。χ~2检验或Fisher确切概率法分析比较不同特征肿瘤患者肌肉减少症患病情况。结果 肿瘤患者中肌肉减少症的患病率为18.1%(11175/61627)。肌肉减少症患病率因肿瘤类型、TNM分期、年龄、性别、地理区域及治疗情况不同而存在差异:消化系统肿瘤患者肌肉减少症患病率较高,其中胰腺癌患者患病率最高[32.4%(311/961)];肌肉减少症患病率随TNM分期增高而增大(P<0.05);70岁以上患者肌肉减少症患病率最高[34.7%(3510/10129)];女性肿瘤患者肌肉减少症患病率高于男性患者[16.1%(5544/34381)比20.7%(5631/27246),P<0.05];东北地区的患者患病率最低[14.7%(2398/16300)],接受手术治疗的患者患病率最高[22.1%(1635/7412)]。此外,在某些肿瘤类型中,不同医疗保险类型、职业、教育水平、民族、居住地的患者肌肉减少症患病率存在显著性差异,文化水平低、农民患者发生肌肉减少症的风险更高。结论 本研究首次以大规模数据报告了肿瘤患者肌肉减少症的患病率,消化道系统、老年、农民、低教育水平及进展期肿瘤患者等是发生肌肉减少症的高风险人群。
【Abstract】 Objective This study aims to investigate the prevalence of sarcopenia specifically in Chinese patients with malignant tumors. Method A total of 61 627 patients with 19 types of malignant tumors from 86 grade-A hospitals from July 2013 to December 2023 were included in the INSCOC database of the Chinese Tumor Nutrition Cohort Study. The diagnostic criteria for sarcopenia provided by the Asian Working Group on Sarcopenia( AWGS) in 2019 were used. Chi-square test or Fisher exact test was used to compare the prevalence of sarcopenia in patients with different population characteristics. Result The prevalence of sarcopenia in cancer patients was 18. 1%. The prevalence of sarcopenia varied with tumor type, TNM stage, age, gender, administrative area and treatment. The prevalence of sarcopenia was higher in patients with digestive system cancers, and the highest prevalence was found in patients with pancreatic cancer [ 32. 4%( 311/961) ]. The prevalence of sarcopenia increased with the increase of TNM stage(P<0. 05). The prevalence of sarcopenia was the highest in patients over 70 years old [ 34. 7%( 3510/10 129) ]. The prevalence of sarcopenia in female cancer patients was higher than that in male patients [16. 1%(5544/34 381) vs 20. 7%(5631/27 246),P<0. 05].The lowest prevalence was found in the Northeast region [ 14. 7%( 2398/16 300) ]. Patients who received surgical treatment had the highest prevalence [22. 1%( 1635/7412) ]. In addition, in some tumor types, there were significant differences in the prevalence of sarcopenia among patients with different medical insurance types, occupation, education level, ethnicity, and place of residence.Patients with low education level and farmers had a higher risk of sarcopenia. Conclusion This study is the first to report the incidence of sarcopenia in tumor patients on a large scale, with a prevalence of 18%. Patients with digestive system cancers, elderly, farmers,low education level and advanced tumor are high risk groups for sarcopenia.
【Key words】 Malignant tumor； Sarcopenia； Appendicular skeletal muscle mass index； Current investigation； Prevalence； Influencing factors； Aged； Digestive system；
- 【文献出处】 肿瘤代谢与营养电子杂志 ,Electronic Journal of Metabolism and Nutrition of Cancer , 编辑部邮箱 ,2024年05期
- 【分类号】R730
- 【下载频次】59