【摘要】 目的 评估气象因素与疟疾发病的相关关系，为制定输入性疟疾防控措施提供依据。方法 计算机检索PubMed、Web of Science、Medline、Embase、CNKI、万方和维普数据库，查找2023年6月24日前发表的关于疟疾与气象因素相关性的文献。按照事先规定的纳入排除标准筛选文献、提取信息进行meta分析和亚组分析。结果 共检出相关文献1 811篇，最终纳入14篇文献，涉及16个地区。meta分析结果显示滞后的气象因素与疟疾发病具有一定的关系，平均气温、平均最高气温、平均最低气温、平均相对湿度和降水量均与疟疾发病呈正相关，合并效应值r_s值分别为0.49(95%CI:0.33-0.63),0.39(95%CI:0.20-0.55),0.49(95%CI:0.33-0.62),0.28(95%CI:0.13-0.42)和0.37(95%CI:0.21-0.52),差异均有统计学意义(P<0.05)。按样本量、经济情况和气候带分组进行亚组分析，结果显示在以“n<100”为单位的亚组中，平均气温与疟疾发病相关性的异质性下降至68.4%,r_s值为0.53(95%CI:0.37-0.67),呈中等强度正相关。在以“中低等”为单位的分组中，平均气温、平均最高气温、平均最低气温、平均相对湿度的异质性均有不同程度的下降，如平均最高气温的异质性下降至59.7%,降雨量与疟疾发病的相关系数差异无统计学意义，其他气象因素与不分组时无明显差别。在“温带”分组中，平均相对湿度的异质性降至0,r_s值为0.36(95%CI:0.27-0.45)。结论 气象因素在一定程度上影响疟疾的发病。更多还原

【Abstract】 Objective To assess the correlation between meteorological factors and the incidence of malaria in order to provide a basis for the development of preventive and control measures for imported malaria. Methods Computerized searches of PubMed, Web of Science, Medline, Embase, CNKI,Wanfang, and VIP databases were conducted to find literature published before June 24,2023 on the correlation between malaria and meteorological factors. Literature was screened, information was extracted for meta-analysis and subgroup analysis according to pre-specified inclusion exclusion criteria. Results A total of 1 811 relevant papers were detected and finally 14 of them were included covering 16 districts. The results of meta-analysis showed that lagged meteorological factors had a relationship with malaria incidence, mean air temperature, mean maximum air temperature, mean minimum air temperature, mean relative humidity and precipitation were positively correlated with malaria incidence, with combined effect r_s values of 0.49(95% CI:0.33-0.63),0.39(95% CI:0.20-0.55),0.49(95% CI:0.33-0.62),0.28(95% CI:0.13-0.42),and 0.37(95% CI:0.21-0.52),and all differences were statistically significant for comparison(P<0.05).Subgroup analyses by sample size, economic status and climatic zone showed that in the subgroups with “n<100”,the heterogeneity of the association between mean temperature and malaria incidence decreased to 68.4%,with an r_svalue of 0.53(95% CI:0.37-0.67),showing a moderately strong positive association. In the subgroups of “medium-low”,the heterogeneity of mean air temperature, mean maximum air temperature, mean minimum air temperature, and mean relative humidity decreased to different degrees, for example, the heterogeneity of mean maximum air temperature decreased to 59.7%,the correlation coefficients between rainfall and malaria incidence were not statistically significant, and the other meteorological factors were not significantly different from that in the subgroups without the “n<100”. Other meteorological factors were not significantly different from those in the ungrouped scenario. In the “Temperate” subgroup, the heterogeneity of mean relative humidity decreased to zero, with an r_s value of 0.36(95% CI:0.27-0.45). Conclusion It is concluded that meteorological factors affect the incidence of malaria to a certain extent.更多还原