【摘要】 细粒棘球蚴病是由细粒棘球蚴寄生引起的人兽共患寄生虫病，呈世界性流行，严重阻碍着畜牧业的发展和人体健康。目前细粒针对棘球蚴病的药物和手术治疗效果尚不理想，切断传播途径是有效的预防手段，预防性疫苗接种是预防细粒棘球蚴病的有效措施之一。使用潜在的家畜和犬类疫苗来对抗细粒棘球绦虫生命周期的幼虫和成虫阶段可能是生产强效疫苗的关键，而此类免疫疗法通常无法诱导足够的免疫反应。本文基于粗抗原或针对细粒棘球蚴的活疫苗、DNA疫苗、重组蛋白疫苗、系统疫苗学和/计算建模疫苗等的研究进展进行综述，为研发和改进下一代细粒棘球蚴疫苗提供理论参考。更多还原

【Abstract】 Echinococcosis is a human-animal parasitic disease caused by Echinococcus granulosus,which is prevalent worldwide and seriously hinders the development of animal husbandry and human health. At present, drug and surgical treatment of echinococcosis is not satisfactory, and cutting off the transmission route is an effective means of prevention. Prophylactic vaccination is one of the effective measures to prevent echinococcosis. The use of potential livestock and canine vaccines against the larval and adult stages of the echinococcosis life cycle may be key to the production of effective vaccines, and such immunotherapy usually fails to induce an adequate immune response. This paper reviews the progress of research on crude antigen-based or live E. granulosus vaccines, DNA vaccines, recombinant protein vaccines, systemic vaccinology, and/or computational model vaccines to provide theoretical references for the development and improvement of next-generation E. granulosus vaccines.更多还原