【摘要】 本研究介绍了聚丙烯酰胺（PAM）/聚氨酯（PU）耐压缩水凝胶的制备工艺。对水性PU和丙烯酰胺（AM）添加量的影响进行了系统研究，探究了不同PAM/PU水凝胶的耐压缩和抗溶胀性能，并探讨了其在关节软骨替代品中的应用潜力。结果表明，制备的PAM/PU水凝胶具有优异的耐压缩性能、回弹性及韧性。当AM水溶液质量分数为35%、PU （以固含量30%的PU乳液体积计）添加量为4 mL时，制备的AM65PU4 gel的耐压缩性能最优异，最大压缩率可达69%，压缩强度为2.1 MPa。此外，PAM/PU水凝胶显示出良好的抗溶胀性能，AM65PU4 gel去离子水中的平衡溶胀率为15%，碱性条件下为212%，酸性条件下为9%，适合用作关节软骨替代品植入人体，并长期稳定地发挥作用。更多还原

【Abstract】 This study introduced the preparation process of polyacrylamide(PAM)/polyurethane(PU) compression-resistant hydrogels. Firstly, a systematic study was conducted on the effects of addition amounts of water-based PU and acrylamide(AM). Furtherly, the preformance of compression and swelling resistance of different PAM/PU hydrogels were investigated, and the potential of its application in articular cartilage substitutes was discussed. The results indicated that the prepared PAM/PU hydrogels exhibited excellent compressive strength, resilience, and toughness. When the mass fraction of AM aqueous solution was 35%, and the amount of PU(calculated by the volume of PU emulsion, solid content of 30%) added was 4 mL, the prepared AM65PU4 gel showed the most excellent compression-resistant performance, with the maximum compression rate up to 69%, and the compression strength of 2.1 MPa. In addition, the hydrogel showed good swelling resistance.The equilibrium swelling rate of AM65PU4 gel in deionized water was 15%, in alkaline condition was 212%, and in acid condition was 9%, which was suitable for use as articular cartilage, and could function stably for a long period of time.更多还原