【摘要】 <正>非戈替尼(filgotinib, GLPG0634,1,图1),英文化学名称为 N-(5-{4-[(1,1-dioxidothiomorpholino)methyl]phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide, 中文化学名称为N-(5-{4-[(1,1-二氧代-4-硫代吗啉基)甲基]苯基}-[1,2,4]三唑并[1,5-a]吡啶-2-基)环丙烷甲酰胺,更多还原

【Abstract】 A variety of synthetic pathways for the selective JAK1 inhibitorf ilgotinib were systematically reviewed. Among these pathways,t he method D-2 emerged as the most favorable option due to thes horter duration,simplified operational procedures,and a noti-c eable enhancement in yield and purity.更多还原