【摘要】 目的 优化盐酸决奈达隆的合成工艺。方法 以5-硝基水杨醛为起始原料，经醚化、水解、环合、傅克酰化、脱甲基反应得到关键中间体2-丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃，再经醚化、还原、甲磺酰化和成盐反应得到目标化合物盐酸决奈达隆。结果与结论目标化合物及关键中间体的结构均经~1H-NMR谱确证，目标化合物总收率为44.7%,纯度为99.9%,产品质量符合《欧洲药典》标准。优化后的工艺简化了实验操作，产品质量易于控制，更有利于实现工业化生产。更多还原

【Abstract】 Dronedarone hydrochloride is an approved drug for the treatment of arrhythmia.A new route to dronedarone hydrochloride was optimized on the base of references and laboratory verification.Using 5-nitrosalicylaldehyde as the starting material, the target compound was afforded by etherification, hydrolysis, cyclization, Friedel-Crafts acylation, demethylation, etherification, reduction, methane sulfonylation and salt formation, with a total yield of 44.7% and purity of 99.9%(HPLC).The improved synthetic process has the advantages of simple operation, mild reaction conditions, lower technology costs, high yield and purity, which is more suitable for industrial production.更多还原