【摘要】 目的 对儿童原发性红斑性肢痛症探索以脊髓电刺激为基础的多模式镇痛方案，及多药联合治疗的药学监护要点。方法 临床药师参与1例原发性红斑性肢痛症伴皮肤感染的患儿治疗过程，结合国内外文献，针对该患儿疾病治疗的难点制定多模式镇痛方案并进行药学监护。结果 治疗团队针对该患儿采取以脊髓电刺激为基础的多模式镇痛治疗，包括不同镇痛药理靶点的多药联合、多种给药途径（口服、静脉、硬膜外、经皮）、多技术（脊髓电刺激、局部神经阻滞、患者自控镇痛）、辅助治疗的个体化方案，并监护用药的安全性。患儿住院及出院后随访期间双足疼痛得到了控制，创面愈合，无严重不良反应发生。结论 以脊髓电刺激为基础的多模式镇痛是治疗儿童原发性红斑性肢痛症安全、有效的方式。更多还原

【Abstract】 OBJECTIVE To explore a multimodal analgesia regimen based on spinal cord electrical stimulation for children with primary erythromelalgia and the key points of pharmaceutical care. METHODS Clinical pharmacists participated in the treatment of a child with primary erythromelalgia complicated with skin infection. After reviewing domestic and foreign literature, multimodal analgesia was formulated and pharmaceutical care was carried out to address the difficulties in treating the patient’s illness. RESULTS The treatment team applied multimodal analgesia based on spinal cord electrical stimulation for the child, including a multi-drug combination involving different analgesic pharmacological targets, multiple administration routes(oral, intravenous, epidural, percutaneous), multiple technologies(spinal cord electrical stimulation, local nerve block, patientcontrolled analgesia), individualized schemes of adjuvant therapy, and the child was monitored for the safety of drug use. The pain was controlled during the treatment and follow-up period, the wound was healed, and no serious adverse drug reactions occurred. CONCLUSIONS Multimodal analgesia based on spinal cord electrical stimulation is a safe and effective treatment for children with primary erythromelalgia.更多还原