【摘要】 目的 分析2005—2020年北京市丰台区接受艾滋病抗逆转录病毒治疗(ART)病例的生存状况及影响因素。方法 收集中国艾滋病综合防治信息系统中丰台区2005—2020年参加艾滋病抗病毒治疗病例数据资料，进行回顾性队列研究，采用寿命表法计算生存率，利用Cox比例风险回归模型分析生存时间的影响因素。结果 共纳入研究对象3 417例，因艾滋病引起相关死亡40例，接受艾滋病抗病毒治疗后第1、3、5、10、15年累计生存率分别为99.24%、99.02%、98.83%、97.05%、97.05%。多因素Cox模型分析结果显示，与15～29岁年龄组、CD4~+T淋巴细胞计数≥500个/μl相比，≥50岁(HR=3.46,95%CI:1.00～11.90)、基线CD4~+T淋巴细胞计数<200个/μl(HR=12.71,95%CI:1.70～95.25)是参加ART病例死亡的独立危险因素。结论 2005—2020年北京市丰台区参加ART的艾滋病病例生存率较高。但仍需继续加强早发现、早治疗工作，重点关注高年龄段病例，加强治疗效果的相关监测，进一步降低艾滋病相关死亡率。更多还原

【Abstract】 Objective To study the status and associated factors of survival in patients with antiretroviral therapy(ART) initiated in 2005-2020 for human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS) in Fengtai District of Beijing.Methods A retrospective cohort study was conducted on the follow-up data of patients with ART initiated from 2005 to 2020 in Fengtai District collected from the National HIV/AIDS Comprehensive Control and Prevention Information System. The life table method was used to calculate the survival rate. Cox proportional hazards regression model was employed to explore associated factors of survival time.Results A total number of 3 417 cases were enrolled. In total, there was 40 HIV/AIDS-related deaths. The cumulative survival rate of patients at 1, 3, 5, 10, and 15 years after ART was 99.24%, 99.02%, 98.83%, 97.05%, and 97.05%, respectively. Multivariate analysis using Cox proportional hazards model revealed that the risk of death was higher in patients aged ≥50 years than that in those aged 15-29 years(HR=3.46,95%CI:1.00-11.90), and was higher in patients with baseline CD4~+ lymphocyte count<200 cells/μl than in those with baseline CD4~+ lymphocyte count ≥ 500 cells/μl(HR=12.71,95%CI:1.70-95.25).Conclusion The survival rate is relatively high in the study population. To further reduce HIV/AIDS related mortality, early detection and treatment, and monitoring of treatment effect should be continuously strengthened, and high-level attention should be paid to patients of older age.更多还原