节点文献
慢性阻塞性肺疾病患者预后营养指数与抑郁症状的关联
Association of prognostic nutritional index with depressive symptoms in patients with chronic obstructive pulmonary disease
【摘要】 目的 探索慢性阻塞性肺疾病(COPD)患者预后营养指数与抑郁症状的关联。方法 选取2005至2018年国家健康和营养检查调查数据库筛选出年龄>40岁慢性阻塞性肺疾病患者2 441例,根据健康问卷-9(PHQ-9)评估抑郁症状,将预后营养指数(PNI)根据中位数(P50)分为两组(>P50高YNI组,≤P50为低PNI组),建立线性回归模型,评估预后营养指数与抑郁的关系。结果 COPD患者2 441例中557例有抑郁症状,抑郁和COPD患者的年龄、性别、婚姻状况、种族、教育程度、吸烟、体重指数、预后营养指数、抑郁评分、慢性病合并情况比较,差异有统计学意义(P<0.05),在多因素logistic回归模型中,高PNI(B=-0.04,95%CI=-0.08~-0.01)是COPD患者抑郁的影响因素(P=0.013)。在男性、丧偶/离异/分居、合并三个及以上的慢性病患者是高PNI患者抑郁的影响因素(P<0.05)。结论 COPD疾病患者高水平预后营养指数有可能成为抑郁风险的影响因素。
【Abstract】 Objective To explore the relationship between prognostic nutritional index and depressive symptoms in patients with chronic obstructive pulmonary disease(COPD). Methods A total of 2 441 patients with COPD age>40 years were selected from the National Health and Nutrition Examination Survey database from 2005 to 2018. Depressive symptoms were assessed according to the patient health questionnaire-9(PHQ-9), and prognostic nutrition index(PNI) was divided into two groups according to the median(P50)( >P50 was high PNI group, ≤P50 was low PNI group), a linear regression model was established to evaluate the relationship between prognostic nutrition index and depression. Results Among the 2 441 COPD patients, 557 had depressive symptoms. There were statistically significant differences in age, sex, marital status, race, education level, smoking, body mass index, prognostic nutrition index, depression score and chronic disease combination between depression and COPD patients(P<0.05). High PNI(B=-0.04, 95%CI=-0.08~-0.01) was the influencing factor of depression in COPD patients(P=0.013). Male, widowed/divorced/separated, combined with three or more chronic diseases were the influential factors for depression in patients with high PNI(P<0.05). Conclusion High levels of prognostic nutritional indices in patients with COPD may be a influence factor for depression risk.
- 【文献出处】 中国当代医药 ,China Modern Medicine , 编辑部邮箱 ,2024年19期
- 【分类号】R563.9;R749.4
- 【下载频次】15