【摘要】 目的 探讨血管活性肠肽（VIP）水平在糖尿病神经源性膀胱（DNB）患者中的表达意义。方法 选取2021年1月至2023年5月九江市第一人民医院内分泌科收治的60例2型糖尿病（T2DM）患者作为研究对象，按照是否伴有DNB分为研究1组和研究2组，其中27例合并DNB患者设为研究1组，其余33例单纯糖尿病患者设为研究2组，选取同期在医院行健康体检的30例健康者设为对照组。抽取所有受试者空腹抽取10 ml肘静脉血，检测血糖[糖化血红蛋白（Hb A1c）、空腹血糖（FPG）]、血脂[总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）]、VIP。比较三组患者血糖、血脂和VIP水平差异，分析血清VIP及血糖、血脂与T2DM患者DNB发生的相关性。结果 单因素分析结果显示，研究1组、研究2组Hb A1c、FPG、VIP检测值均高于对照组，且研究1组各指标检测值高于研究2组，差异有统计学意义（P<0.05）。研究1组、研究2组TG、TC、LDL-C检测值均高于对照组，且研究1组各指标检测值高于研究2组，差异有统计学意义（P<0.05）；三组患者HDL-C检测值比较，差异无统计学意义（P>0.05）;Hb A1c、FPG、VIP、TG、TC、LDL-C水平与T2DM患者DNB发生呈正相关（r=0.621、0.614、0.337、0.353、0.459、0.265,P<0.05）。结论 DNB患者血清VIP明显升高，可作为早期筛查DNB的有效指标。更多还原

【Abstract】 Objective To investigate the expression of vasoactive intestinal peptide(VIP) in patients with diabetic neurogenic bladder(DNB). Methods A total of 60 patients with type 2 diabetes mellitus(T2DM) admitted to the Department of Endocrinology of Jiujiang NO.1 People’s Hospital from January 2021 to May 2023 were selected as study subjects. They were divided into study group 1 and study group 2 according to whether they were accompanied by DNB. Among them, 27patients with DNB were assigned as study group 1, and the remaining 33 patients with simple diabetes were assigned as study group 2. Thirty healthy subjects who underwent physical examination in hospital during the same period were selected as control group, 10 ml of elbow venous blood was extracted from all subjects on an empty stomach, and blood glucose(hemoglobin [Hb A1c], fasting blood glucose [FPG]), blood lipid(total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C]) and VIP were detected. The differences of blood glucose, blood lipid and VIP levels among the three groups were compared, and the correlation between serum VIP,blood glucose, blood lipid and DNB occurrence in T2DM patients were analyzed. Results The results of single factor analysis showed that the Hb A1c, FPG and VIP detection values of study group 1 and study group 2 were higher than those of control group, and the detection values of each index of study group 1 were higher than those of study group 2, with statistical significances(P<0.05). The values of TG, TC and LDL-C in study group 1 and study group 2 were higher than those in control group, and the values of all indexes in study group 1 were higher than those in study group 2, with statistical significances(P<0.05). There was no significant difference in HDL-C detection value among the three groups(P>0.05).The levels of Hb A1c, FPG, VIP, TG, TC and LDL-C were positively correlated with DNB occurrence in T2DM patients(r=0.621, 0.614, 0.337, 0.353, 0.459, 0.265, P<0.05). Conclusion Serum VIP is significantly elevated in DNB patients,which can be used as an effective index for early DNB screening.更多还原