【摘要】 目的：探讨高强度间歇训练（high-intensity interval training,HIIT）和中等强度持续训练（moderate-intensity continuous training,MICT）对肥胖男大学生血管内皮功能和血流剪切力的影响及其可能机制。方法：将52名18～22岁、BMI≥30 kg·m^-2的肥胖男大学生分为HIIT组（n=21）、MICT组（n=22）和CON组（n=9），对HIIT组(运动强度为80%～95%HR_max)和MICT组(运动强度为60%～70%HR_max)进行为期8周的运动干预。测定运动前、后受试者身体形态、身体机能、血脂、血管内皮功能和血流动力学指标。采用Endo PAT-2000系统测试指端反应性充血指数（reactivity hyperemia index,RHI）；采用彩色多普勒超声诊断技术测定受试者运动前、后血管管径（vascular diameter,VD）、血流速度（blood flow velocity,BFV）和血流剪切力（wall shear stress,WSS）等血流动力学指标。结果：与运动前相比，8周HIIT和MICT显著改善肥胖男大学生身体形态指标（P<0.01），但HIIT组与MICT组组间差异不显著（P>0.05）；运动后，HIIT组和MICT组RHI显著高于CON组（P<0.01）,HIIT组比MICT组高0.223，但未达到显著性水平（P>0.05）。与运动前相比，HIIT组和MICT组WSS和BFV均显著增大（P<0.01）,CON组无显著性变化（P>0.05）;HIIT组和MICT组组间差异不显著（P>0.05），但HIIT组和MICT组WSS和BFV均显著高于CON组（P<0.05）。与运动前相比，HIIT组和MICT组VD无显著变化（P>0.05）,CON组VD有上升趋势，但差异不显著（P>0.05）,HIIT组与MICT组组间差异也不显著（P>0.05）。运动前、后WSS的变化程度与RHI（r=0.541,P<0.001）、BFV（r=0.957,P<0.001）的变化程度呈显著正相关，与LDL（r=-0.322,P<0.05）、VD（r=-0.399,P<0.05）的变化程度呈显著负相关。结论：1)8周HIIT和MICT均能够有效改善肥胖男大学生身体形态、血管内皮功能及血流动力学相关参数。2)HIIT和MICT提高肥胖男大学生血管内皮功能的相关机制，可能与HIIT和MICT后WSS的增加有关。3)HIIT改善血管内皮功能，可能与高WSS降低LDL浓度有关。更多还原

【Abstract】 Objective:To explore the effects of high-intensity interval training （HIIT） and moder,ate-intensity continuous training （MICT） on vascular endothelial function and wall shear stress in obese male college students and its possible mechanism.Methods:Fifty-two obese male col,lege students aged 18 to 22 years with BMI≥30 kg·m^-2 were divided into 3 groups:HIIT group（n=21）,MICT group （n=22）,and CON group （n=9）.The HIIT group (exercise intensity:80%～95%HR_max) and MICT group (exercise intensity:60%～70%HR_max) received an eight-week exer,cise intervention.Body shape,body function,blood lipids,vascular endothelial function and he,modynamics were measured before and after exercise.The Endo PAT-2000 system was used to detect the fingertip reactive hyperemia index （RHI） before and after intervention;the color Dop,pler ultrasound diagnostic technology was used to test the vessel diameter （VD）,blood flow ve,locity （BFV）,and wall shear stress （WSS） before and after the intervention.Meanwhile,the body shape,blood pressure,heart rate,and blood lipid parameters were measured.Results:Compared with before exercise,after eight weeks intervention,body shape index,blood pressure,and heart rate in HIIT group and MICT group were significantly improved （P<0.01）,but there was no significant difference between HIIT group and MICT group （P>0.05）;after exercise,the RHI in HIIT group and MICT group were significantly higher than CON group （P<0.01）,the RHI in HIIT group was 0.223 higher than MICT group,but there was no significant difference be,tween two exercise groups （P>0.05）.Compared with before exercise,the WSS and BFV in HI,IT group and MICT group increased significantly （P<0.01）,while there was no significant dif,ference in the CON group （P>0.05）;the WSS and BFV had no significant difference between the HIIT group and MICT group （P>0.05）,but the WSS and BFV in HIIT group and MICT group were significantly higher than CON group （P<0.05）.Compared with before exercise,the VD did not change significantly between HIIT group and MICT group （P>0.05）,and the VD in CON group had an upward trend,but it was no significant difference （P>0.05）.The changes of WSS before and after exercise were positively correlated with the changes of RHI （r=0.541,P<0.001） and BFV （r=0.957,P<0.001）,and negatively correlated with the changes of LDL（r=-0.322,P<0.05） and VD （r=-0.399,P<0.05）.Conclusions:1) Both HIIT and MICT exer,cises for eight weeks could effectively enhance the vascular endothelial function and hemody,namic parameters in obese male college students.2) HIIT and MICT could improve vascular en,dothelial function in obese male college students and its mechanisms may be related to the in,creased wall shear stress after HIIT and MICT.3) HIIT significantly improved vascular endothe,lial function,which may be related to high wall shear stress-inhibited LDL concentration.更多还原