【摘要】 目的 探讨核受体亚家族2E组成员1(NR2E1)与代谢相关脂肪性肝病（MAFLD）患者慢性炎症状态的相关性。方法 选取2021年10月至2022年10月于中南大学湘雅医学院附属海口医院内分泌科治疗的MAFLD患者32例（MAFLD组），另选取37名同期体检健康者为正常对照（NC）组。检测两组血清TG、TC、LDL-C、HDL-C、谷丙转氨酶（ALT）、谷草转氨酶（AST）、谷氨酰转肽酶（GGT）、FPG、FIns、HbA1c、TNF-α、IL-6及IL-1β，计算胰岛素抵抗指数（HOMA-IR）。结果 MAFLD组BMI、TC、TG、LDL-C、ALT、AST、GGT、HbA1c、FIns、FPG、HOMA-IR高于NC组（P<0.05或P<0.01）,MAFLD组NR2E1mRNA及蛋白表达高于NC组（P<0.05或P<0.01）,MAFLD组TNF-α、IL-6、IL-1β高于NC组（P<0.01）。Pearson相关分析显示，NR2E1与ALT、FIns、HOMA-IR、TNF-α、IL-6、IL-1β呈正相关（P<0.05）。多元线性回归分析显示，IL-1β是NR2E1的影响因素。结论 MAFLD患者NR2E1升高与IR及慢性炎症状态相关。更多还原

【Abstract】 Objective To investigate the relationship between nuclear receptor subfamily 2 group E member 1(NR2E1)and chronic inflammatory status in metabolic associated fatty liver disease(MAFLD).Methods A total of 32 MAFLD patients who were treated in the Endocrinology Department of Haikou Affiliated Hospital of Central South University XiangYa School of Medicine were enrolled in this study from October 2021 to October 2022 as MAFLD group. And 37 healthy individuals who underwent physical examinations during the same period were selected as the normal control(NC) group. Serum TG,TC,LDL-C,HDL-C,ALT,AST,GGT,FPG,FIns,HbA1c,TNF-α,IL-6 and IL-1β were detected in each group. Calculate insulin resistance index(HOMA-IR) was calculated in each group. Results The BMI,TC,TG,LDL-C,ALT,AST,GGT,HbA1c,FIns,FPG,HOMA-IR were higher in the MAFLD group than in the NC group(P<0. 05 or P<0. 01);the mRNA and protein expression of NR2E1 were higher in the MAFLD group than in the NC group(P<0. 05 or P<0. 01). TNF-α,IL-6,and IL-1β were higher in the MAFLD group than in the NC group(P<0. 01). Pearson correlation analysis showed that NR2E1 was positively associated with ALT,FIns,HOMA-IR,TNF-α,IL-6 and IL-1β(P<0. 05). Multiple linear regression analysis showed that IL-1β was the influencing factor for NR2E1. Conclusion The increase of NR2E1 may be related to insulin resistance and chronic inflammation in MAFLD patients.更多还原