【摘要】 目的：自主神经失平衡在阵发性心房颤动起重要作用，该研究探索经皮耳迷走神经刺激（ta-VNS）在肺静脉隔离（PVI）术中有效性。方法：按照纳入标准及排除标准，连续入组阵发性心房颤动射频消融患者，共入组120例心房颤动患者，平均年龄（64.3±8.6）岁。随机分2组，观察组（PVI+ta-VNS）和对照组（PVI+假taVNS）各60例。使用华佗刺激仪于耳迷走神经区域进行刺激，刺激时间为整个消融过程。主要终点：单次消融后，空白期至随访结束，无心房颤动复发患者的比例。每3个月进行门诊/电话随访，第12月中期分析。结果：中位随访时间16.5个月，12个月无心房颤动发生率在观察组和对照组分别81.6%和70%(P<0.05)。结论：在阵发性心房颤动的PVI+ta-VNS较PVI+假ta-VNS更有效和更安全。更多还原

【Abstract】 Objective: Autonomic imbalance plays a significant role in paroxysmal atrial fibrillation(PAF). This study investigates the efficacy of transcutaneous auricular vagus nerve stimulation (ta-VNS) during pulmonary vein isolation (PVI) procedures.Methods:Following inclusion and exclusion criteria,120 patients with paroxysmal atrial fibrillation undergoing radiofrequency ablation were consecutively enrolled,with an average age of (64.3±8.6) years.They were randomly divided into two groups:the observation group (PVI+ta-VNS) and the control group (PVI+sham ta-VNS),with 60 patients in each.Stimulation of the auricular vagus nerve region was conducted using a Hua Tuo stimulator throughout the ablation process.The primary endpoint was the proportion of patients without atrial fibrillation recurrence after a single ablation procedure,up to the end of the follow-up period.Follow-up was conducted every 3 months through outpatient visits or phone calls,with an interim analysis at 12 months.Results:The median follow-up time was 16.5 months,with a 12-month atrial fibrillationfree rate of 81.6%in the observation group and 70%in the control group (P<0.05).Conclusion:PVI+ta-VNS is more effective and safer than PVI+sham taVNS in patients with paroxysmal atrial fibrillation.更多还原