【摘要】 背景与目的：收集以医院登记为基础的6 737例接受手术切除的胃癌患者的随访资料，分析其1、3和5年观察总生存（overall survival,OS）率和无病生存（disease-free survival,DFS）率，为中国的胃癌防控和政策制定提供真实世界研究证据。方法：纳入2015年1月1日—2020年12月31日在复旦大学附属肿瘤医院接受手术治疗的胃癌患者共6 737例，通过查阅患者病史了解患者的临床信息，并通过复诊病史、电话随访和死因数据链接等方式收集患者的生存随访资料，随访统计时间截至2023年11月30日。采用Kaplan-Meier法估计患者1、3和5年OS率和DFS率，并在不同年龄组、性别、治疗时期、肿瘤分期及病理学特征等亚组中分别描述。结果：接受手术切除的胃癌患者经中位50.99个月随访后，5年OS率和Ⅰ～Ⅲ期患者5年DFS率分别为70.37%和69.46%。Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期胃癌患者的5年OS率分别为94.32%、82.56%、51.01%和23.97%。不同年龄、部位、大体分型、Borrmann分型和Laurence分型的患者生存有显著差异。结论：肿瘤分期是影响胃癌患者生存的重要因素，应加强人群（尤其是高危人群）胃癌的筛查和早诊早治，进一步改善患者的生存。更多还原

【Abstract】 Background and purpose: Follow-up data of 6 737 patients undergoing surgery for gastric cancer were collected based on hospital registration, and the 1-, 3- and 5-years observed overall survival(OS) rates and disease-free survival(DFS) rates were analyzed to provide real-world research evidence for the prevention and control of gastric cancer and policy making in China.Methods: A total of 6 737 gastric cancer patients who underwent surgical treatment at Fudan University Shanghai Cancer center from 2015 to 2020 were included in this study. Clinical information and the follow-up endpoint data were collected through medical records review, telephone visits and death registry data linkage. The last follow-up date was November 30, 2023. Kaplan-Meier method was applied in evaluating the 1-, 3- and 5-year OS rate and DFS rate, and survival data were described by different subgroups including age group, gender, treatment period, tumor staging, and pathological characteristics. Results: With a median follow-up time of 50.99 months, the 5-year OS rate of surgically resected gastric cancer patients was 70.37%, and 5-year DFS rate in Ⅰ-Ⅲ stage cases was 69.46%. The 5-year OS rates of stage Ⅰ, Ⅱ, Ⅲ and Ⅳ were 94.32%, 82.56%, 51.01% and 23.97%, respectively. The differences in survival among patients with different age, tumor location, gross classification, Borrmann classification and Laurence classification were significant. Conclusion: Staging is an important factor directly affecting the survival of gastric cancer patients.Screening and early diagnosis and treatment in large population, especially high-risk group, should be strengthened to further improve the patients’ survival.更多还原