【摘要】 目的 探讨儿童人偏肺病毒(human metapenu-movirus,hMPV)肺炎的临床特征。方法 收集2023年4月至2024年3月入住安徽医科大学第一附属医院儿科的70例hMPV肺炎患儿的临床资料,分析儿童hMPV肺炎的流行病学特点、临床表现、实验室及影像学特点、治疗和转归。结果 儿童hMPV肺炎多见于在5岁儿童(55例),发病集中在春季(36例),54.3%患儿合并细菌感染。临床症状、体征:咳嗽(70例),发热(65例),气促(7例)、喘息(19例)。48例肺部可闻及啰音,其中湿啰音38例。34例患儿C反应蛋白升高,7例患儿降钙素原升高。X线胸片:斑片状阴影55例,肺实变7例,网格状、磨玻璃影8例。治疗:合并细菌感染应用抗菌药物38例,应用糖皮质激素治疗29例,肺泡灌洗9例,氧疗2例,应用丙种球蛋白治疗1例,均未予抗病毒药物,无机械通气。患儿住院天数3～15d,平均住院5.7d。所有患儿均好转出院。结论 儿童hMPV肺炎≤5岁儿童易感,集中在春季。hMPV肺炎患儿均有咳嗽,多伴发热,较易合并细菌感染,整体预后良好。更多还原

【Abstract】 Objective To explore the clinical characteristics of human metapenu-movirus(hMPV) pneumonia in children.Methods Epidemiological characteristics clinical manifestation, laboratory examination, imaging features, treatment and outcome of 70 hMPV pneumonia in children who were admitted to Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University from April 2023 to March 2024 were collect and analyzed. Results hMPV pneumonia predominantly affected children under 5 years old(55 cases), with a higher incidence in spring(36 cases), and 54.3% with bacterial infection.Clinical manifestation included coughing(70 cases), fever(65 cases), breathlessness(7 cases), and wheezing(19 cases). 48 cases had lung rales, 38 cases were wet rales. 34 cases showed elevated C-reactive protein and elevated procalcitonin in 7 cases. Chest X-ray showed 55 cases of patchy shadows, 7 cases of lung consolidation, and 8 cases of gridded or ground glass shadows. 38cases were complicated with bacterial infections and treated with antibiotics, 29 cases were treated with glucocorticoids, 9 cases with bronchoalveolar lavage, 2 cases with oxygen therapy, and 1 case with immunoglobulin, none required antiviral drugs or mechanical ventilation. Hospital stays varied between 3 and 15 days, averaged at 5.7 days. All cases improved and were discharged from the hospital. Conclusion hMPV pneumonia usually occurs in children less than or equal to 5 years old, and tends to occur in spring. Children with hMPV pneumonia were mainly characterized by fever and cough, bacterial co-infection is more common. The overall prognosis is good.更多还原