【摘要】 目的：探讨柏薏灌肠液联合丹白颗粒治疗盆腔炎性疾病后遗症(湿热瘀结证)的临床疗效。方法：选取2021年3月至2023年3月该院收治的盆腔炎性疾病后遗症(湿热瘀结证)患者90例，采用随机数字表法分为中药灌肠组、中药颗粒组和联合组，每组30例。中药灌肠组患者采用常规治疗+柏薏灌肠液，中药颗粒组患者采用常规治疗+丹白颗粒，联合组患者采用常规治疗+柏薏灌肠液+丹白颗粒。治疗3个月经周期后，评估三组患者的临床疗效、中医证候积分、血流动力学、炎症因子和治疗安全性。结果：联合组患者的总有效率为93.33%(28/30),高于中药灌肠组、中药颗粒组的70.00%(21/30)、66.67%(20/30),差异均有统计学意义(P<0.05)。治疗后，联合组患者中医证候积分(包括腰骶胀痛、经行不畅、带下增多和舌红苔黄积分)低于中药灌肠组、中药颗粒组，差异均有统计学意义(P<0.05)。治疗后，联合组患者子宫动脉收缩期最大流速、舒张末期最大流速和搏动指数高于中药灌肠组、中药颗粒组，阻力指数低于中药灌肠组、中药颗粒组，差异均有统计学意义(P<0.05)。治疗后，联合组患者炎症因子[白细胞介素18、前列腺素E2和β淀粉样前体蛋白]水平低于中药灌肠组、中药颗粒组，差异均有统计学意义(P<0.05)。联合组、中药灌肠组和中药颗粒组患者的不良反应发生率分别为13.33%(4/30)、10.00%(3/30)和6.67%(2/30),组间差异无统计学意义(P>0.05)。结论：柏薏灌肠液联合丹白颗粒治疗盆腔炎性疾病后遗症(湿热瘀结证)的效果良好，可改善患者中医证候，提高盆腔子宫动脉血流动力学，抑制炎症因子水平，安全性良好。更多还原

【Abstract】 OBJECTIVE: To probe into the clinical efficacy of Baiyi rectal solution combined with Danbai granules in the treatment of sequelae of pelvic inflammatory disease(damp-heat stasis type). METHODS: Totally 90 patients with sequelae of pelvic inflammatory disease(damp-heat stasis type) admitted into the hospital from Mar. 2021 to Mar. 2023 were extracted to be divided into the traditional Chinese medicine enema group, traditional Chinese medicine granule group and combined group via the random number table method, with 30 cases in each group. The traditional Chinese medicine enema group was treated with conventional treatment + Baiyi rectal solution, the traditional Chinese medicine granule group was given conventional treatment + Danbai granules, and the combined group received conventional treatment + Baiyi rectal solution + Danbai granules. After 3 menstrual cycles of treatment, the clinical efficacy, traditional Chinese medicine syndrome score, hemodynamics, inflammatory factors and treatment safety of three groups were evaluated. RESULTS: The total effective rate of combined group was 93.33%(28/30), higher than 70.00%(21/30) of traditional Chinese medicine enema group and 66.67%(20/30) of traditional Chinese medicine granule group, with statistically significant differences(P<0.05). After treatment, the scores of traditional Chinese medicine symptom(including lumbosacral swelling pain, poor menses, increased underband, red tongue and yellow fur) in combined group were lower than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, with statistically significant differences(P<0.05). After treatment, the systolic maximum flow velocity, end-diastolic maximum flow velocity and pulsation index of uterine artery in combined group were higher than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, and the resistance index was lower than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, with statistically significant differences(P<0.05). After treatment, the levels of inflammatory factors(interleukin-18, prostaglandin E2 and β amyloid precursor protein) in combined group were lower than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, with statistically significant differences(P<0.05). The incidences of adverse drug reactions in combined group, traditional Chinese medicine enema group and traditional Chinese medicine granule group were respectively 13.33%(4/30), 10.00%(3/30) and 6.67%(2/30), with no statistically significant difference(P>0.05). CONCLUSIONS: The efficacy of Baiyi rectal solution combined with Danbai granules in the treatment of sequelae of pelvic inflammatory disease(damp-heat stasis type) is significant, which can improve the traditional Chinese medicine symptom of patients, increase the hemodynamics of patients’ pelvic uterine artery, inhibit the level of inflammatory factors with higher safety.更多还原