【摘要】 目的 为老年糖尿病住院患者合理用药提供依据。方法 收集山东第一医科大学附属省立医院内分泌科2021年1月1日至12月31日收治的老年（年龄≥65岁）糖尿病住院患者的电子病历，采用美国老年医学会（AGS）Beers标准（2019版，简称Beers标准）和中国老年人潜在不适当用药判断标准（2017年版，简称中国标准）分别评价患者潜在不适当用药（PIM）情况，采用二元Logistic回归分析评估PIM发生的相关危险因素。结果 共纳入患者563例，其中男260例、女303例，平均年龄（71.66±5.99）岁，平均住院天数（9.18±3.20）d，平均患病（7.82±2.73）种。Beers标准和中国标准检测到的PIM患者分别为254例（45.12%,462例次）和229例（40.67%,359例次），2种标准对于PIM发生的判断结果比较无显著差异（P=0.061）。阿普唑仑、胰岛素（滑动剂量）、抗精神病药（奥氮平）、多沙唑嗪、吲哚美辛为2种标准判断出的共有PIM，其中阿普唑仑在2种标准评价结果中的占比均排前3。二元Logistic回归分析显示，用药数量、住院天数在2种标准评价结果中均与老年糖尿病住院患者发生PIM显著相关（P <0.05）。结论 老年糖尿病住院患者的PIM发生率较高，临床应结合2种标准进行判断，以提高用药的有效性和安全性，降低药物相关的毒副反应，保障临床合理用药。更多还原

【Abstract】 Objective To provide a basis for rational drug use in elderly inpatients with diabetes mellitus (DM).Methods The electronic medical records of the elderly inpatients(aged ≥ 65 years) with DM admitted to the Department of Endocrinology of the Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 1 to December 31,2021 were collected. The American Geriatrics Society 2019 Updated AGS Beers Criteria?for Potentially Inappropriate Medication Use in Older Adults(hereinafter referred to as the Beers Criteria) and the Criteria of Potentially Inappropriate Medications for Older Adults in China(2017 Edition,hereinafter referred to as the Chinese Criteria) were used to evaluate the potentially inappropriate medication(PIM) of patients,and the binary Logistic regression analysis was used to evaluate the risk factors related to PIM.ResultsA total of 563 patients were included,including 260 males and 303 females,with an average age of(71. 66 ± 5. 99) years,an average hospital stay of(9. 18 ± 3. 20) d,involving(7. 82 ± 2. 73) varieties of diseases. A total of 254 patients(45. 12%,462 cases) and229 patients(40. 67%,359 cases) were involved in PIM based on the Beers Criteria and the Chinese Criteria respectively. The results of PIM evaluation by the two criteria was similar(P = 0. 061). Alprazolam,insulin(sliding scale),antipsychotic drug(olanzapine),doxazosin and indomethacin were both evaluated as the drugs related to PIM by the two criteria,in which the cases of PIM involving alprazolam were both in the top three based on the two criteria. The binary Logistic regression analysis showed that the number of medications and hospital stay were both significantly correlated with PIM in elderly inpatients with DM based on the two criteria(P < 0. 05).ConclusionThe incidence of PIM in elderly inpatients with DM is high,we should evaluate it according to the Beers Criteria and the Chinese Criteria to improve the effectiveness and safety of drug use,reduce the drug-related toxic and side effects,and ensure the rational drug use in clinical practice.更多还原