【摘要】 目的 探讨儿童药物性肝损伤（DILI）研究的分布特点、发展现状和趋势热点，并与DILI总体研究情况进行对比，为儿童DILI研究提供参考。方法 检索Web of Science核心合集数据库中1999年1月1日至2023年3月22日发表的儿童DILI及DILI相关文献，采用CiteSpace 6.1. R6 Advance软件对儿童DILI及DILI相关研究的发文量、国家/地区、机构、关键词进行可视化分析。结果 共检索到相关文献18 757篇，最终纳入4 640篇，包括儿童DILI 334篇和DILI 4 306篇。可视化分析结果显示，DILI发文量总体呈稳定上升趋势，儿童DILI发文量处于波动状态，无明显发展趋势；美国、中国发文量分别位居第1,2位，研究机构以国外高校、医院、职能监督机构为主；关键词分析提示，DILI研究侧重发病机制、相关共病、诊治评估、风险预测、疾病管理等方面，并有与新的数据处理、分析技术相结合的趋势；儿童DILL集中于DILI相关风险的基础研究，趋向于DILI的风险管理。结论 应创新DILI的研究模式，重视和深入研究儿童DILI的发病机制、风险预测和疾病管理。更多还原

【Abstract】 Objective To investigate the distribution characteristics,development status,and trend hotspots of the research on drug-induced liver injury(DILI) in children,and to compare those with the overall research on DILI to provide a reference for the research of DILI in children.MethodsThe Web of Science database was searched for collecting DILI-related literature in children and DILI-related literature published from January 1,1999 and March 22,2023. Citespace 6. 1R6 Advance software was used to visualize and analyze the number of publications,countries/regions,institutions,and keywords of DILI in children and DILI-related literature.ResultsA total of 18 757 relevant studies were retrieved,and 4 640 studies were ultimately included,including 334 studies of DILI in children and 4 306 studies of DILI. The visualization analysis results showed that the overall number of published studies related to DILI showed a stable upward trend,while the number of published studies related to DILI in children was fluctuating with no obvious development momentum. The United States of American(USA) and China rank first and second in terms of the number of publications,and the research institutions were mainly related to foreign universities,hospitals,and functional supervision institutions. The keyword analysis of DILI studies focused on pathogenesis,related comorbidities,diagnosis and treatment evaluation,risk prediction,disease management,and it was gradually combined with emerging data processing and analysis technologies. The studies on DILI in children was more focused on basic research on DILI-related risks,with a trend towards risk management.ConclusionIt is recommended to innovate DILI research models,emphasize and conduct in-depth researches on the mechanisms,risk prediction,and disease management of DILI in children.更多还原