【摘要】 目的 探讨老年住院患者衰弱与估算肾小球滤过率（eGFR）的关系。方法 收集2022年6月至2023年6月在北京积水潭医院老年医学科住院的400例老年人的临床资料。根据eGFRCr-Cys公式，将其分为正常组[eGFR≥60 ml/（min·1.73m~2）]280例、下降组[eGFR<60 ml/（min·1.73m~2）]120例。比较两组临床资料。采用logistic回归分析老年住院患者eGFR下降的影响因素。结果 两组年龄、身高、体重、离异/丧偶、高血压病、骨质疏松、慢性疼痛、听觉障碍、视觉障碍、咀嚼障碍、Edmonton衰弱量表总分、低密度脂蛋白胆固醇（LDL-C）、丙氨酸转氨酶、白蛋白、血肌酐、胱抑素C、血钾、血钠、乳酸脱氢酶、总胆固醇、甘油三酯比较，差异有统计学意义（P<0.05）。多因素分析显示，年龄（OR=1.075,95%CI:1.033～1.118）、高血压病（OR=2.164,95%CI:1.144～4.096）、Edmonton衰弱量表总分（OR=1.366,95%CI:1.211～1.541）、LDL-C(OR=1.790,95%CI:1.398～2.292)是老年住院患者eGFR下降的独立影响因素（P<0.05）。结论 老年住院患者eGFR下降与多种因素相关，其中年龄、高血压病、Edmonton衰弱量表总分、LDL-C为其独立影响因素，具有较大的预测价值，可为临床识别eGFR下降高危患者提供参考。更多还原

【Abstract】 Objective To explore the association between frailty and estimated glomerular filtration rate(eGFR) in elderly hospitalized patients. Methods Clinical data of 400 elderly hospitalized patients admitted to Department of Geriatric,Beijing Jishuitan Hospital, Capital Medical University from June 2022 to June 2023 were colected. According to eGFRCr-Cys formula, they were divided into two groups: 280 cases in the normal group [eGFR ≥ 60 ml/(min·1.73m~2)] and 120 cases in the decline group [eGFR < 60 ml/(min·1.73m~2)]. Clinical data of the two groups were compared. Influencing factors of eGFR decline in elderly hospitalized patients were analyzed through logistic regression analysis. Results There were statistically significant differences in age, height, weight, divorce/widowhood, hypertension, osteoporosis, chronic pain,hearing impairment, visual impairment, chewing impairment, Edmonton frailty scale total score, low-density lipoprotein cholesterol(LDL-C), alanine aminotransferase, albumin, serum creatinine, cystatin C, potassium, sodium, lactate dehydrogenase, total cholesterol, triglyceride between the two groups(P <0.05). Multivariate analysis showed that age(OR=1.075, 95%CI: 1.033-1.118), hypertension(OR=2.164, 95% CI: 1.144-4.096), Edmonton frailty scale total score(OR=1.366, 95%CI: 1.211-1.541), and LDL-C(OR=1.790, 95%CI: 1.398-2.292) were independent influencing factors of eGFR decline in elderly hospitalized patients(P<0.05). Conclusion The eGFR decline in elderly hospitalized patients is related to multiple factors, among which age, hypertension, Edmonton frailty scale total score, and LDL-C are independent influencing factors with significant predictive value, which can provide reference for clinical identification of eGFR decline in high-risk patients.更多还原