【摘要】 目的：基于CiteSpace和VOSviewer可视化软件对饮食限制(DR)调控炎症文献进行定量可视化分析，探索DR调控炎症领域的研究热点和趋势。方法：检索2010年1月1日至2022年9月29日WebofScience核心数据库中收录的DR调控炎症相关文献共1 678篇，经筛查最终获得1 344篇，使用CiteSpace和VOSviewer可视化软件对检索到的文献数据进行年发文量、国家、机构、作者、被引频次和关键词的定量和可视化分析。结果：最终获得的1 344篇文献年发文量总体呈上升趋势，文献最高被引频次为1 676次，美国(481篇)是出产文献数量最多的国家，中国(181篇)位居第二。DR调控炎症领域研究热点集中在热量限制(CR)、生酮饮食、衰老、代谢性疾病、脂肪组织及肠道菌群等方面。结论：DR调控炎症愈来愈受到国际和国内研究者青睐，未来研究热点可能是CR模拟物(CRM)、肠道菌群、神经退行性疾病和心血管疾病，总体研究趋势为进一步明确DR的抗炎机制，寻找新的治疗靶点，将更多经过体外和动物模型证实的有效方案进行更严格的临床试验。更多还原

【Abstract】 Objective: To conduct visualization analysis on the literature on dietary restriction(DR) regulating inflammation based on CiteSpace and VOSviewer visualization software, and to explore research hotspots and trends in this field. Methods: The literature on DR regulation inflammation in Web of Science core databases from January 1 2010 to September 29 2022 were searched. CiteSpace and VOSviewer visualization software was used to conduct quantitative and visual analysis of the annual publication volume, countries, institutions, authors,citation frequency and keywords of the retrieved literature. Results: A total of 1 344 papers related to the topic were included, and the annual number of papers was generally on the rise, with the highest citation frequency of 1 676times. The United States(481 papers) is the country with the largest number of publications, followed by China(181 papers). The research hotspots in this field focused on calorie restriction(CR), ketogenic diet, aging, metabolic diseases, adipose tissue and gut microbiota. Conclusion: DR regulation of inflammation is increasingly favored by international and domestic researchers, and future research hotspots may be CR mimics(CRMs), intestinal microbiota,neurodegenerative diseases and cardiovascular diseases. The overall research trend is to further clarify the antiinflammatory mechanism of DR, find new therapeutic targets, and conduct more rigorous clinical trials with more effective regimens that have been proven in vitro and animal models.更多还原