【摘要】 目的 研究阻塞性睡眠呼吸暂停（OSA）患者血清P2X7受体（P2X7R）和核因子-κB(NF-κB)水平与认知功能障碍的相关性。方法 选择2021年10月至2022年12月期间青海省人民医院收治的126例OSA患者作为OSA组，进一步根据蒙特利尔认知评估量表（MoCA）评分分为MoCA评分<26分的认知功能障碍组（n=68）和MoCA评分≥26分的认知功能正常组（n=58）；另取同期体检的健康志愿者作为对照组（n=105）。检测血清P2X7R、NF-κB水平，采用logistic回归模型分析OSA患者认知功能障碍的影响因素，采用ROC曲线分析各指标对OSA患者认知功能障碍的诊断价值。结果 OSA组患者的血清P2X7R、NF-κB水平高于对照组，差异有统计学意义（t=17.295、7.088,P<0.05）；认知功能障碍组患者的血清P2X7R、NF-κB水平高于认知功能正常组，差异有统计学意义（t=8.469、8.497,P<0.05）；血清P2X7R、NF-κB水平升高是OSA患者认知功能障碍的危险因素（P<0.05）;OSA患者血清P2X7R、NF-κB水平与MoCA评分呈负相关（P<0.05）；血清P2X7R、NF-κB水平诊断OSA患者认知功能障碍的曲线下面积分别为0.862(95%CI:0.800～0.923,P<0.05)和0.859(95%CI:0.794～0.923)。结论 OSA患者血清P2X7R、NF-κB水平升高且与认知功能障碍相关，血清P2X7R、NF-κB对OSA患者认知功能障碍具有诊断效能。更多还原

【Abstract】 Objective To investigate the correlation between serum P2X7 receptor(P2X7R)and nuclear factor-κB(NF-κB)levels and cognitive dysfunction in patients with obstructive sleep apnea(OSA).Methods 126 OSA patients admitted to Qinghai Provincial People’s Hospital from October 2021 to December 2022 were selected for the OSA group. They were divided into a cognitive dysfunction group with a MoCA score <26(n=68)and a normal cognitive function group with a MoCA score ≥ 26(n=58)based on the Montreal Cognitive Assessment(MoCA)score. Healthy volunteers who underwent physical examinations during the same period were chosen as the control group(n=105). The levels of serum P2X7R and NF-κB were tested,and the influencing factors of cognitive dysfunction in OSA patients were analyzed using a logistic regression model. Additionally,the diagnostic value of each indicator for cognitive dysfunction in OSA patients was assessed using a ROC curve. Results The levels of serum P2X7R and NF-κB in the OSA group were higher than those in the control group,and the differences were statistically significant(t=17.295,7.088,P<0.05).The levels of serum P2X7R and NF-κB in the cognitive dysfunction group were higher than those in the normal cognitive function group,and the difference was statistically significant(t=8.469,8.497,P<0.05). The increased levels of serum P2X7R and NF-κB were identified as risk factors for cognitive dysfunction in OSA patients(P<0.05). Serum P2X7R and NF-κB levels were found to be negatively correlated with MoCA scores in OSA patients(P<0.05). The areas under the curve for serum P2X7R and NF-κB levels in the diagnosis of cognitive dysfunction in OSA patients were 0.862(95%CI:0.800～0.923,P<0.05)and 0.859(95%CI:0.794～0.923,P<0.05). Conclusion The levels of serum P2X7R and NF-κB in OSA patients are increased and correlated with cognitive dysfunction. Serum P2X7R and NF-κB have diagnostic value for identifying OSA patients with cognitive dysfunction.更多还原