【摘要】 脊髓损伤（spinal cord injury,SCI）是严重影响中枢神经系统的疾病，其中氧化应激在SCI的继发性损伤中扮演关键角色。本文阐述了氧化应激在SCI中的作用、主要信号通路及现有治疗方法。重点关注Nrf-2、PI3K/AKT、TLR4/MyD88等通路在氧化应激调控中的作用，并探讨抗氧化疗法在减轻SCI症状中的潜力，旨在对深入理解SCI和优化治疗策略提供参考。更多还原

【Abstract】 Spinal cord injury(SCI) is a disease that profoundly impacts the central nervous system, with oxidative stress playing a crucial role in its secondary damage. This article provides a comprehensive review of the role of oxidative stress in SCI, its primary signaling pathways, and current treatment methods. It focuses particularly on the functions of pathways such as Nrf-2, PI3K/AKT, and TLR4/MyD88 in the regulation of oxidative stress and explores the potential of antioxidant therapies in alleviating SCI symptoms. This paper aims to offer insights for a deeper understanding of SCI and provide reference for optimizing treatment strategies.更多还原