【摘要】 目的 探讨福州市1 073例HIV/AIDS患者抗病毒治疗的效果和耐药情况，为进一步完善艾滋病抗病毒治疗提供依据。方法 采用回顾性调查方法，收集2019年1月-2020年12月在福州市接受抗病毒治疗的1 073例HIV/AIDS患者的资料，评价抗病毒治疗后患者的CD4~+T淋巴细胞计数、病毒载量以及耐药情况，评价抗病毒治疗效果、免疫功能、抗病毒药物耐药情况。结果 1 073例HIV/AIDS患者中，抗病毒治疗后病毒完全抑制798例(74.37%),抗病毒治疗失败39例(3.63%)。免疫功能正常411例(38.30%)。CD4~+T淋巴细胞计数和病毒载量存在负相关关系(r_s=-0.166,P<0.001)。39例抗病毒治疗失败患者中，耐药发生率为20.51%(8/39),对核苷酸类反转录酶抑制剂(NRTIs)和非核苷类反转录酶抑制剂(NNRTIs)的耐药发生率分别为15.38%(6/39)、17.95%(7/39),对NRTIs和NNRTIs的多重耐药发生率为12.82%(5/39)。结论 福州市HIV/AIDS患者抗病毒治疗效果良好，耐药发生率总体较低。更多还原

【Abstract】 Objective To discuss the effect of antiretroviral therapy(ART) and drug resistance for 1 073 AIDS/HIV patients in Fuzhou city, so as to provide reference for further improvement of AIDS antiretroviral therapy. Methods A retrospective survey was conducted to collect the data of 1 073 HIV/AIDS patients who received antiviral treatment in Fuzhou city from January 2019 to December 2020.The CD4~+T lymphocyte count, viral load and drug resistance of the patients after antiviral treatment were evaluated, and the antiviral treatment effect, immune function and drug resistance were evaluated. Results Among the 1 073 cases, complete viral suppression was achieved in 798 patients(74.37%) through antiviral treatment.Treatment failure was observed in 39 cases(3.63%).A total of 411 patients(38.30%) exhibited normal immune function.The CD4~+ T lymphocyte count and viral load exhibit a negative correlation(r_s=-0.166,P<0.001).Among 39 patients who failed antiviral treatment, the incidence of drug resistance was 20.51%(8/39).The incidence of resistance to nucleotide reverse transcriptase inhibitors(NRTIs) and non nucleoside reverse transcriptase inhibitors(NNRTIs) was 15.38%(6/39) and 17.95%(7/39),respectively.The incidence of multidrug resistance to NRTIs and NNRTIs was 12.82%(5/39). Conclusion The antiretroviral therapy in Fuzhou city has shown good efficacy, with an overall low occurrence rate of drug resistance.更多还原