【摘要】 目的 探究茶摄入量与抑郁障碍风险的因果关联。方法 使用茶摄入量相关的遗传变异数据作为工具变量，使用抑郁障碍的全基因组关联数据作为结局变量。采用逆方差加权法（IVW）作为孟德尔随机化（MR）的主要分析方法，并将MR-Egger等方法作为补充估计。结果 最终纳入41个SNPs进入分析，IVW分析结果显示OR=1.04,P_IVW=0.54,即饮茶与抑郁障碍风险无明确因果关系。敏感性分析显示主要结果稳健，无离群值，MR-Presso检验得到了一致的关联效应估计。MR-Egger回归分析未发现潜在多效性。结论 本研究从遗传学角度未能提供饮茶降低抑郁障碍风险的证据。更多还原

【Abstract】 Objective To explore the causal association between tea intake and risk of depression. Methods A two-sample Mendelian randomization analysis was performed using Genome-wide Association Study（GWAS） summary data. Inverse variance weighted（IVW） was used as the primary estimate of Mendelian randomization（MR）, with additional methods serving as supplementary estimates. Sensitivity analysis was conducted using the MR-PRESSO test and MR-Egger regression. Results Forty-one SNPs were eventually included in the analysis, and IVW analysis showed no clear causal relationship between tea intake and risk of depression(OR=1.04, P_IVW=0.54). MR-PRESSO test provided consistent estimates of association effects. MR-Egger regression analysis did not find pleiotropy. Conclusion The present study failed to provide evidence that tea intake reduces the risk of depression from a genetic perspective. We therefore need more experimental studies in the future to elucidate the potential causal association between tea intake and the risk of depression.更多还原