【摘要】 阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠呼吸障碍性疾病。作为一种重要的全球公共卫生问题，未经治疗的OSA可导致多种不良的健康后果，包括各种心脑血管疾病、代谢紊乱以及焦虑、抑郁等精神心理疾病。气道正压通气（PAP）、减肥、口腔矫正器、上气道手术、体位疗法等传统的OSA疗法主要针对OSA的解剖学因素。然而，OSA的发病机制是异质性的，非解剖学因素对大多数患者同样发挥着重要的作用。尽管目前尚无疗效确切的药物用于治疗OSA，但是随着人们对OSA病理生理机制的认识更加深刻，越来越多的临床研究致力于药物治疗OSA及其合并症的研究，并取得了一系列成果。本文将对近几年药物治疗OSA的相关研究作一综述，以为将来药物治疗OSA的相关研究提供文献支持及理论依据。更多还原

【Abstract】 Obstructive sleep apnea(OSA) is a common sleep disordered breathing disorder. As a major global public health problem, untreated OSA can lead to a variety of adverse health outcomes,including various cardiovascular and cerebrovascular diseases, metabolic disorders, and psychiatric disorders such as anxiety and depression. Traditional OSA therapies such as positive airway pressure(PAP), weight loss, oral appliance, upper airway surgery, and postural therapy focus on the anatomical factors of OSA. However, the pathogenesis of OSA is heterogeneous, and non-anatomical factors also play an important role in most patients. Although there is no drug with exact efficacy for the treatment of OSA, with the deepening understanding of the pathophysiological mechanism of OSA, more and more clinical studies are devoted to the study of drug treatment of OSA and its complications,and a series of results have been achieved. The following is a review of the relevant studies on drug treatment of OSA in recent years, hoping to provide literature support and theoretical basis for future research on drug treatment of OSA.更多还原