【摘要】 膜联蛋白A2(ANXA2)是一种钙离子依赖的磷脂结合蛋白，属于高度保守的多基因膜联蛋白家族成员，具有调节细胞增殖、钙稳态和促进细胞膜修复作用。ANXA2参与了炎症反应、自噬、凋亡等过程，同时还在心血管疾病发生发展中具有重要作用。本文主要就ANXA2的结构、功能及其在心血管疾病[如动脉粥样硬化（AS）、脑卒中、心肌梗死（MI）等疾病]中的作用作一综述，旨在提高对ANXA2在心血管疾病中的认识，为心血管疾病的防治提供新方向。更多还原

【Abstract】 Annexin A2(ANXA2) is a calcium-dependent phospholipid binding protein, which belongs to a highly conserved multi-gene annexin family member. It has the functions of regulating cell proliferation,calcium homeostasis and promoting cell membrane repair. ANXA2 is also involved in inflammatory response,autophagy, apoptosis and other processes, and also plays an important role in the occurrence and development of cardiovascular diseases. This article reviews the structure and function of ANXA2 and its role in cardiovascular diseases such as atherosclerosis(AS), stroke, and myocardial infarction(MI), aiming to improve the understanding of ANXA2 in cardiovascular diseases and provide a new direction for the prevention and treatment of cardiovascular diseases.更多还原