【摘要】 目的 探讨喉咽清口服液联合奥司他韦治疗儿童流行性感冒的效果及对血红素氧合酶-1(HO-1)、巨噬细胞迁移抑制因子（MIF）和半胱氨酰白三烯（CysLTs）水平的影响。方法 选取2022年2月至2023年2月我院收治的100例流行性感冒患儿，以随机数字表法将其分为对照组（50例，奥司他韦）和观察组（50例，喉咽清口服液联合奥司他韦）。比较两组的治疗效果。结果 观察组的治疗总有效率高于对照组，差异具有统计学意义（P<0.05）。观察组的发热消失时间、咳嗽消失时间、咽痛消失时间、流涕消失时间、乏力消失时间均短于对照组，差异具有统计学意义（P<0.05）。治疗后，观察组的HO-1水平高于对照组，MIF、CysLTs水平低于对照组，差异具有统计学意义（P<0.05）。治疗后，观察组的免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平均高于对照组，差异具有统计学意义（P<0.05）。结论 喉咽清口服液联合奥司他韦治疗儿童流行性感冒的效果较好，可有效改善临床症状，减轻机体炎症反应，调节免疫功能，值得推广。更多还原

【Abstract】 Objective To investigate the effect of Houyanqing oral liquid combined with oseltamivir in the treatment of influenza in children and its influences on the levels of heme oxygenase-1(HO-1), macrophage migration inhibitory factor(MIF) and cysteinyl leukotrienes(CysLTs). Methods A total of 100 children with influenza admitted in our hospital from February 2022 to February 2023 were selected and divided into control group(50 cases, oseltamivir) and observation group(50 cases, Houyanqing oral liquid combined with oseltamivir) by random number table method. The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). The disappearance time of fever, cough, sore throat, runny nose and fatigue in the observation group were shorter than those in the control group, and the differences were statistically significant(P<0.05). After treatment, the level of HO-1 in the observation group was higher than that in the control group, the levels of MIF and CysLTs were lower than those in the control group, and the differences were statistically significant( P < 0. 05). After treatment, the levels of immunoglobulin A(IgA), immunoglobulin G(IgG) and immunoglobulin M(IgM) in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion Houyanqing oral liquid combined with oseltamivir is effective in the treatment of influenza in children, it can effectively improve clinical symptoms, reduce inflammatory response and regulate immune function, which is worthy of promotion.更多还原